Yu Huan, Yuan Lunzhi, Yan Zhigang, Zhou Ming, Ye Jianghui, Wu Kun, Chen Wenjia, Chen Rirong, Xia Ningshao, Guan Yi, Zhu Huachen
Guangdong-Hong Kong Joint Laboratory of Emerging Infectious Diseases/Joint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases (Key Laboratory of Ministry of Education), Joint Institute of Virology (Shantou University/The University of Hong Kong), Shantou University Medical College, Shantou 515063, China.
State Key Laboratory of Vaccines for Infectious Diseases, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen 361102, China.
Int J Mol Sci. 2023 Sep 16;24(18):14191. doi: 10.3390/ijms241814191.
Butyrate, produced by gut microbe during dietary fiber fermentation, has anti-inflammatory and antioxidant effects on chronic inflammation diseases, yet it remains to be explored whether butyrate has protective effects against viral infections. Here, we demonstrated that butyrate alleviated tissue injury in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected golden hamsters supplemented with butyrate before and during the infection. Butyrate-treated hamsters showed augmentation of type I interferon (IFN) response and activation of endothelial cells without exaggerated inflammation. In addition, butyrate regulated redox homeostasis by enhancing the activity of superoxide dismutase (SOD) to inhibit excessive apoptotic cell death. Therefore, butyrate exhibited effective prevention against SARS-CoV-2 by upregulating antiviral immune responses and promoting cell survival.
肠道微生物在膳食纤维发酵过程中产生的丁酸盐，对慢性炎症性疾病具有抗炎和抗氧化作用，但丁酸盐对病毒感染是否具有保护作用仍有待探索。在此，我们证明，在感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的金黄仓鼠感染前及感染期间补充丁酸盐，可减轻组织损伤。经丁酸盐处理的仓鼠表现出I型干扰素（IFN）反应增强和内皮细胞活化，且无过度炎症反应。此外，丁酸盐通过增强超氧化物歧化酶（SOD）的活性来调节氧化还原稳态，以抑制过度的凋亡性细胞死亡。因此，丁酸盐通过上调抗病毒免疫反应和促进细胞存活，对SARS-CoV-2表现出有效的预防作用。
