Department of Applied Biotechnology, Ajou University, Suwon 16499, Republic of Korea.
R&D Complex, Kolmar Korea, Seocho 06800, Republic of Korea.
Int J Mol Sci. 2023 Sep 19;24(18):14294. doi: 10.3390/ijms241814294.
The use of face masks during the COVID-19 pandemic resulted in significant societal changes, particularly for individuals with sensitive skin. To address this issue, the researchers explored traditional medicine and identified extract as a potential solution due to its anti-inflammatory and moisturizing effects. This research investigated how this extract influences skin hydration, barrier function, and itching. The findings revealed that the extract had a hydrating effect by elevating Aquaporin-3 (AQP3) expression. Additionally, the study demonstrated that the extract improved skin barrier function, with Filaggrin (FLG) expression being approximately three times higher ( < 0.001) in the -extract-treated group compared to the control group and the genes associated with itching being reduced. In this process, we researched and developed HPβCD (hydroxypropyl-β-cyclodextrin)-Liposome containing extract, gradually and sustainably releasing the active components of the extract. During four weeks of clinical trials involving individuals wearing masks for over 6 h a day, a moisturizer containing extract demonstrated a notable reduction in skin redness. Hemoglobin values (A.U.), which serve as indicators of skin redness, showed decreases of 5.06% and 6.74% in the test area inside the mask after 2 and 4 weeks, respectively, compared to the baseline measurements. Additionally, the moisturizer containing extract notably decreased Trans Epidermal Water Loss (TEWL), with reductions of 5.23% and 9.13% observed in the test area inside the mask after 2 and 4 weeks, respectively. The moisturizer, especially in the test area treated with the extract-containing moisturizer, significantly enhanced skin hydration compared to the control group. The Corneometer values (A.U) exhibited notable increases of 11.51% and 15.14% in the test area inside the mask after 2 and 4 weeks, respectively. These discoveries emphasize the potential of extract and its utility in tackling skin issues caused by mask wearing, including enhancing moisture, fortifying the skin's barrier, and alleviating itching. These results indicate that moisturizers incorporating specific ingredients provide greater benefits compared to conventional moisturizers.
在 COVID-19 大流行期间，口罩的使用导致了重大的社会变化，特别是对敏感皮肤的人。为了解决这个问题，研究人员探索了传统医学，并确定 提取物是一种潜在的解决方案，因为它具有抗炎和保湿作用。本研究调查了这种提取物如何影响皮肤的水分、屏障功能和瘙痒。研究结果表明，该提取物通过提高水通道蛋白 3（AQP3）的表达具有保湿作用。此外，研究表明，提取物改善了皮肤屏障功能，-提取物处理组的 Filaggrin（FLG）表达大约是对照组的三倍（<0.001），与瘙痒相关的基因减少。在这个过程中，我们研究和开发了含有 提取物的 HPβCD（羟丙基-β-环糊精）-脂质体，逐渐和可持续地释放 提取物的活性成分。在一项涉及每天戴口罩超过 6 小时的个体的四周临床试验中，含有 提取物的保湿剂显著减少了皮肤发红。血红蛋白值（AU）作为皮肤发红的指标，在 2 周和 4 周时，口罩内测试区域分别下降了 5.06%和 6.74%，与基线测量值相比。此外，含有 提取物的保湿剂显著降低了经表皮水分流失（TEWL），在 2 周和 4 周时，口罩内测试区域分别下降了 5.23%和 9.13%。与对照组相比，保湿剂，特别是含有提取物的保湿剂处理的测试区域，显著增强了皮肤的水分。经皮水分流失计（Corneometer）值（AU）在 2 周和 4 周时，口罩内测试区域分别显著增加了 11.51%和 15.14%。这些发现强调了 提取物的潜力及其在解决口罩佩戴引起的皮肤问题方面的效用，包括增强水分、强化皮肤屏障和缓解瘙痒。这些结果表明，含有特定成分的保湿剂比传统保湿剂提供更大的益处。
