Payani Elnaz, Koliogiannis Dionysios, Schoenberg Markus Bo, Koch Dominik, Eser-Valeri Daniela, Denk Gerald, Rehm Markus, Schäfer Simon, Ehmer Ursula, Kremer Andreas E, Meiser Bruno, Werner Jens, Guba Markus, Börner Nikolaus
Department of General-, Visceral- and Transplant Surgery, LMU University Hospital, 81377 Munich, Germany.
Transplant Center Munich, LMU University Hospital, 81377 Munich, Germany.
J Clin Med. 2023 Sep 10;12(18):5880. doi: 10.3390/jcm12185880.
This observational study focuses on the characteristics and survival of patients taken off of the liver transplant waiting list. Assessment of post-delisting survival and a frequent follow-up of patients after delisting are important keys to improve the survival rate of patients with liver failure after being delisted. Within this study, delisted liver transplant candidates were divided into the following groups: (1) "too good" (54%) or (2) "too sick" (22%) for transplantation, (3) adherence issues (12%) or (4) therapy goal changed (11%). The 5-year survival after delisting within these groups was 84%, 9%, 50%, and 68%, respectively. Less than 3% of the delisted patients had to be relisted again. The clinical expert decision of the multidisciplinary transplant team was sufficiently accurate to differentiate between patients requiring liver transplantation and those who were delisted after a stable recovery of liver function. The assessment of post-delisting survival may serve as a complementary metric to assess differences in center practices and to estimate cumulative post-delisting mortality risk.
这项观察性研究聚焦于从肝移植等候名单上移除的患者的特征及生存情况。评估移除名单后的生存情况以及对患者移除名单后进行频繁随访,是提高肝衰竭患者移除名单后的生存率的重要关键。在本研究中,被移除肝移植候选资格的患者被分为以下几组:(1) “情况太好”(54%)或(2) “病情太重”(22%)而无法进行移植,(3) 依从性问题(12%)或(4) 治疗目标改变(11%)。这些组内移除名单后的5年生存率分别为84%、9%、50%和68%。不到3%的被移除名单的患者必须再次进入等候名单。多学科移植团队的临床专家决策足够准确,能够区分需要肝移植的患者和肝功能稳定恢复后被移除名单的患者。对移除名单后生存情况的评估可作为一种补充指标,用于评估各中心做法的差异以及估计移除名单后的累积死亡风险。