Petrova Tereza, Brudnicki Andrzej, Kotova Magdalena, Urbanova Wanda, Dubovska Ivana, Polackova Petra, Voborna Iva, Fudalej Piotr S
Department of Stomatology, 3rd Faculty of Medicine, Charles University and Kralovske Vinohrady University Hospital, 10034 Prague, Czech Republic.
Institute of Dentistry and Oral Sciences, Faculty of Medicine and Dentistry, Palacký University Olomouc, 77900 Olomouc, Czech Republic.
J Clin Med. 2023 Sep 15;12(18):5985. doi: 10.3390/jcm12185985.
The degree of deviation of palatal shape from the norm may reflect facial growth disturbance in cleft lip and palate (CLP). The objective of this study was to compare the palatal morphology in children treated with different surgical protocols. Palatal shape was assessed with geometric morphometrics (GM) including Procrustes superimposition, principal component analysis (PCA), and permutation tests with 10,000 permutations, in 24 children treated with two-stage repair with a late palatoplasty (Prague group; mean age at assessment 8.9 years), 16 children after two-stage repair with early palatoplasty (Bratislava group; mean age 8.2 years), and 53 children treated with a one-stage repair (Warsaw group, mean age 10.3 years). The non-cleft control group comprised 60 children at 8.6 years. The first five principal components (PCs) accounted for a minimum of 5% of the total shape variability (65.9% in total). The Procrustes distance was largest for the Prague vs. Control pair and smallest for the Prague vs. Bratislava pair. Nonetheless, all intergroup differences were statistically significant ( < 0.01). One can conclude that variations in palatal shape roughly correspond to cephalometric and dental arch relationship findings from prior research. Among the children who underwent a one-stage repair of the complete cleft, their palatal morphology most closely resembled that of the non-cleft controls. Conversely, children who received late palatoplasty exhibited the greatest degree of deviation.
腭部形态与正常标准的偏离程度可能反映唇腭裂（CLP）患者的面部生长紊乱情况。本研究的目的是比较采用不同手术方案治疗的儿童的腭部形态。通过几何形态测量法（GM）评估腭部形态，包括普氏叠加、主成分分析（PCA）以及进行10000次置换的置换检验，研究对象包括24例接受两阶段修复且腭裂修复较晚的儿童（布拉格组；评估时平均年龄8.9岁）、16例接受两阶段修复且腭裂修复较早的儿童（布拉迪斯拉发组；平均年龄8.2岁）以及53例接受一阶段修复的儿童（华沙组，平均年龄10.3岁）。非腭裂对照组由60例8.6岁的儿童组成。前五个主成分（PCs）至少占总形状变异的5%（总计65.9%）。布拉格组与对照组之间的普氏距离最大，布拉格组与布拉迪斯拉发组之间的普氏距离最小。尽管如此，所有组间差异均具有统计学意义（<0.01）。可以得出结论，腭部形态的变化大致与先前研究中的头影测量和牙弓关系结果相符。在接受完全性腭裂一阶段修复的儿童中，他们的腭部形态与非腭裂对照组最为相似。相反，接受腭裂修复较晚的儿童表现出最大程度的偏离。
