Barreto Marina Dos Santos, Silva Beatriz Soares da, Santos Ronaldy Santana, Silva Deise Maria Rego Rodrigues, Silva Eloia Emanuelly Dias, Moura Pedro Henrique Macedo, Souza Jessiane Bispo de, Santana Lucas Alves da Mota, Fonseca Dennyson Leandro M, Filgueiras Igor Salerno, Guimarães Adriana Gibara, Cabral-Marques Otavio, Schimke Lena F, Borges Lysandro Pinto
Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil.
Graduate Program in Dentistry, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil.
Life (Basel). 2023 Sep 16;13(9):1925. doi: 10.3390/life13091925.
COVID-19 led to the suspension academic activities worldwide, affecting millions of students and staff.
In this study, we evaluated the presence of IgM and IgG anti-SARS-CoV-2 antibodies in an academic population during the return to classes after a one-year suspension. The study took place over five months at a Brazilian university and included 942 participants.
We found that most participants had reactive IgG and non-reactive IgM. All received at least one dose, and 940 received two or more doses, of different COVID-19 vaccines. We obtained a higher average of memory antibodies (IgG) in participants who received the CoronaVac/ChAdOx1 combination. IgG was consistently distributed for each vaccine group, but individuals who completed the vaccination schedule had higher levels. There were no differences between antibodies and gender, presence of symptoms, and previous COVID-19 infection, but older participants (>53 years) and contacts of infected individuals had higher IgM levels.
This study makes significant contributions to the assessment of antibodies in the academic environment, allowing us to infer that most participants had memory immunity and low indications of recent infection when returning to face-to-face classes, as well as demonstrating the need to monitor immunity and update vaccinations.
新型冠状病毒肺炎疫情导致全球学术活动暂停，影响了数百万学生和教职员工。
在本研究中，我们评估了在停课一年后复课期间学术人群中抗新型冠状病毒2 IgM和IgG抗体的存在情况。该研究在巴西一所大学进行了五个月，包括942名参与者。
我们发现大多数参与者IgG呈阳性反应而IgM呈阴性反应。所有人都至少接种了一剂，940人接种了两剂或更多剂不同的新型冠状病毒肺炎疫苗。在接种科兴疫苗/牛津-阿斯利康疫苗组合的参与者中，我们获得了更高的平均记忆抗体（IgG）水平。IgG在每个疫苗组中的分布一致，但完成疫苗接种程序的个体水平更高。抗体与性别、症状的存在以及既往新型冠状病毒肺炎感染之间没有差异，但年龄较大的参与者（>53岁）和感染者的接触者IgM水平较高。
本研究为学术环境中抗体的评估做出了重大贡献，使我们能够推断，大多数参与者在恢复面对面授课时具有记忆免疫且近期感染迹象较少，同时也表明了监测免疫力和更新疫苗接种的必要性。
