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儿童期生育力保存:男科疾病的未来展望

Fertility Preservation in Pediatric Age: Future Perspective among Andrological Diseases.

作者信息

Zampieri Nicola

机构信息

Pediatric Surgical Unit, Pediatric Fertility Lab, Department of Engineering for Innovation Medicine, University of Verona, Piazzale Stefani, n. 1, 37100 Verona, Italy.

Pediatric and Infant Surgery, UniCamillus International Medical University, Via di Sant'Alessandro 8, 00131 Rome, Italy.

出版信息

Life (Basel). 2023 Sep 20;13(9):1934. doi: 10.3390/life13091934.

DOI:10.3390/life13091934
PMID:37763337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10532987/
Abstract

Male infertility is a condition that has always been less studied and known than female infertility. Male infertility is increasingly present and increasingly diagnosed. Although several causes are known, to date about 40% of the causes are considered idiopathic. The worldwide denasality can only be slowed if awareness campaigns are implemented on all the diseases that can alter fertile potential, especially in young adolescents. Male infertility is, in addition, associated with several medical conditions. In particular, the association between infertility and testicular cancer, cardiovascular disease, autoimmune diseases, and genetic diseases is well known. For this reason, fertility preservation should not be proposed or be only oncological in nature, as there are several diagnosable pediatric pathologies that are associated with altered fertile potential to whose patients we could offer a gamete preservation pathway. In this paper we propose our experience on fertility preservation in pediatric andrological diseases.

摘要

男性不育症一直以来都比女性不育症受到的研究和了解更少。男性不育症的发病率越来越高,诊断也越来越多。虽然已知有多种病因,但迄今为止,约40%的病因被认为是特发性的。只有在针对所有可能改变生育潜力的疾病开展提高认识运动的情况下,全球不育率才有望得到缓解,尤其是在青少年中。此外,男性不育症还与多种疾病有关。特别是,不育症与睾丸癌、心血管疾病、自身免疫性疾病和遗传性疾病之间的关联是众所周知的。因此,生育力保存不应该仅局限于肿瘤学范畴,或者根本不被提出,因为有几种可诊断的儿科疾病与生育潜力改变有关,我们可以为这些疾病的患者提供配子保存途径。在本文中,我们将介绍我们在儿科男科疾病生育力保存方面的经验。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa72/10532987/48442a60091f/life-13-01934-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa72/10532987/0b1d77f35f66/life-13-01934-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa72/10532987/18bb14dd7eb5/life-13-01934-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa72/10532987/48442a60091f/life-13-01934-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa72/10532987/0b1d77f35f66/life-13-01934-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa72/10532987/18bb14dd7eb5/life-13-01934-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa72/10532987/48442a60091f/life-13-01934-g003.jpg

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本文引用的文献

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Biology (Basel). 2023 Apr 3;12(4):547. doi: 10.3390/biology12040547.
2
Gonadal function in pediatric Fanconi anemia patients treated with hematopoietic stem cell transplant.儿科范可尼贫血患者造血干细胞移植治疗后的性腺功能。
Haematologica. 2023 Sep 1;108(9):2358-2368. doi: 10.3324/haematol.2022.282094.
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Testicular Tissue Banking for Fertility Preservation in Young Boys: Which Patients Should Be Included?
睾丸组织库用于保存年轻男孩的生育能力:哪些患者应包括在内?
Front Endocrinol (Lausanne). 2022 Mar 10;13:854186. doi: 10.3389/fendo.2022.854186. eCollection 2022.
4
Testicular Torsion: Preliminary Results of In Vitro Cell Stimulation Using Chorionic Gonadotropin.睾丸扭转:使用绒毛膜促性腺激素进行体外细胞刺激的初步结果。
Cells. 2022 Jan 28;11(3):450. doi: 10.3390/cells11030450.
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A new frontier in therapy personalisation based on in vitro studies to preserve fertility potential of men.基于体外研究的治疗个体化的新前沿,以保留男性的生育潜力。
Andrologia. 2022 Feb;54(1):e14244. doi: 10.1111/and.14244. Epub 2021 Sep 7.
6
Twenty-year experience with macro-area school screening for andrological disease in paediatric age.20 年儿童期性腺疾病宏观区域学校筛查经验。
Andrologia. 2021 Dec;53(11):e14209. doi: 10.1111/and.14209. Epub 2021 Aug 11.
7
The Landscape of Coverage for Fertility Preservation in Male Pediatric Patients.男性儿科患者生育力保存的覆盖情况概述
Urol Pract. 2018 May 1;5(3):198-204. doi: 10.1016/j.urpr.2017.03.007. Epub 2017 Mar 27.
8
Fertility preservation in men: a contemporary overview and a look toward emerging technologies.男性生育力保存:当代概述及新兴技术展望。
Fertil Steril. 2021 May;115(5):1126-1139. doi: 10.1016/j.fertnstert.2021.03.026.
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Fertility preservation for male patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group.儿童、青少年和青年期癌症男性患者的生育力保存:PanCareLIFE 联盟和国际儿童癌症晚期效应指南协调组的建议。
Lancet Oncol. 2021 Feb;22(2):e57-e67. doi: 10.1016/S1470-2045(20)30582-9.
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Fertility preservation for pediatric male cancer patients: illustrating contemporary and future options; a case report.儿科男性癌症患者的生育力保存:阐述当代及未来的选择;病例报告
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