Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Fertil Steril. 2021 May;115(5):1126-1139. doi: 10.1016/j.fertnstert.2021.03.026.
Cancer and oncologic therapies can have significant adverse effects on male reproductive potential, leaving many men permanently infertile. Fertility preservation has emerged as a key survivorship issue over the past 20 years, and numerous professional societies have published guidelines calling for fertility preservation to become a routine component of oncologic care. Most males with cancer are able to produce a semen specimen for fertility preservation, but numerous other methods of sperm procurement are available for patients who cannot provide a sufficient sample. Despite these options, fertility preservation will remain a challenge for prepubertal boys and men without sperm production. For these patients, experimental and investigational approaches offer the hope that one day they will translate to the clinical arena, offering additional pathways for successful fertility preservation care.
癌症和肿瘤治疗会对男性的生殖能力产生重大的负面影响，导致许多男性永久性不育。在过去的 20 年中，生育力保存已成为一个关键的生存问题，许多专业协会已经发布了指南，呼吁将生育力保存作为肿瘤治疗的常规组成部分。大多数患有癌症的男性都能够提供精液样本进行生育力保存，但对于无法提供足够样本的患者，还有许多其他的精子获取方法。尽管有这些选择，对于没有精子产生的青春期前男孩和男性来说，生育力保存仍然是一个挑战。对于这些患者，实验和研究方法为他们提供了希望，有一天这些方法将转化为临床领域，为成功的生育力保存护理提供更多途径。
