Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Department of Ophthalmology, Clinical Hospital for Ophthalmological Emergencies, 010464 Bucharest, Romania.
Medicina (Kaunas). 2023 Sep 14;59(9):1660. doi: 10.3390/medicina59091660.
: Hyperopia is a refractive error which affects cognitive and social development if uncorrected and raises the risk of primary angle-closure glaucoma (PACG). : The study included only the right eye-40 hyperopic eyes in the study group (spherical equivalent (SE) under pharmacological cycloplegia over 0.50 D), 34 emmetropic eyes in the control group (SE between -0.50 D and +0.50 D). A complete ophthalmological evaluation was performed, including autorefractometry to measure SE, and additionally we performed Ocular Response Analyser: Corneal Hysteresis (CH), Corneal Resistance Factor (CRF); specular microscopy: Endothelial cell density (CD), Cell variability (CV), Hexagonality (Hex), Aladdin biometry: Anterior Chamber Depth (ACD), Axial Length (AL), Central Corneal Thickness (CCT). IBM SPSS 26 was used for statistical analysis. : The mean age of the entire cohort was 22.93 years (SD ± 12.069), 66.22% being female and 33.78% male. The hyperopic eyes had significantly lower AL, ACD, higher SE, CH, CRF. In the hyperopia group, there are significant, negative correlations between CH and AL (r -0.335), CRF and AL (r -0.334), SE-AL (r -0.593), ACD and CV (r -0.528), CV and CRF (r -0.438), CH (r -0.379), and positive correlations between CCT and CH (r 0.393) or CRF (r 0.435), CD and ACD (r 0.509) or CH (0.384). Age is significantly, negatively correlated with ACD (r -0.447), CH (r -0.544), CRF (r -0.539), CD (r -0.546) and positively with CV (r 0.470). : Our study suggests a particular biomechanical behavior of the cornea in hyperopia, in relation with morphological and endothelial parameters. Moreover, the negative correlation between age and ACD suggests a shallower anterior chamber as patients age, increasing the risk for PACG.
远视是一种屈光不正，如果不矫正，会影响认知和社会发展，并增加原发性闭角型青光眼（PACG）的风险。该研究仅纳入了研究组中 40 只远视眼（药物性睫状肌麻痹下等效球镜度超过 0.50 D）和对照组中的 34 只正视眼（等效球镜度在-0.50 D 至+0.50 D 之间）。对所有患者均进行了全面的眼科评估，包括自动屈光检查以测量等效球镜度，此外还进行了眼反应分析仪：角膜滞后（CH）、角膜阻力因子（CRF）；共焦显微镜：内皮细胞密度（CD）、细胞变异系数（CV）、六边形（Hex）；Aladdin 生物测量仪：前房深度（ACD）、眼轴长度（AL）、中央角膜厚度（CCT）。采用 IBM SPSS 26 进行统计学分析。整个队列的平均年龄为 22.93 岁（标准差±12.069），其中 66.22%为女性，33.78%为男性。远视眼的 AL、ACD 明显较低，SE、CH、CRF 较高。在远视组中，CH 与 AL（r=-0.335）、CRF 与 AL（r=-0.334）、SE-AL（r=-0.593）、ACD 与 CV（r=-0.528）、CV 与 CRF（r=-0.438）、CH（r=-0.379）之间存在显著负相关，而 CCT 与 CH（r=0.393）或 CRF（r=0.435）、CD 与 ACD（r=0.509）或 CH（r=0.384）之间存在显著正相关。年龄与 ACD（r=-0.447）、CH（r=-0.544）、CRF（r=-0.539）、CD（r=-0.546）呈显著负相关，与 CV（r=0.470）呈显著正相关。我们的研究表明，远视眼的角膜具有特定的生物力学行为，与形态学和内皮参数有关。此外，年龄与 ACD 之间的负相关表明，随着患者年龄的增长，前房变浅，PACG 的风险增加。
