Department of Ophthalmology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Eur Rev Med Pharmacol Sci. 2023 Apr;27(8):3580-3589. doi: 10.26355/eurrev_202304_32139.
The purpose of this study was to investigate the relationship between corneal biomechanics and ocular morphology in myopic children and adolescents.
The study included 170 right eyes, from 170 patients under the age of 18 years, who underwent a complete ophthalmologic examination, gathering the following data: spherical equivalent (SE) (under pharmacological cycloplegia), biomechanical parameters - corneal hysteresis (CH) and corneal resistance factor (CRF), structural parameters - axial length (AL) and central corneal thickness (CCT).
The average age of the patients was 15.26 years old (55.29% girls, 44.70% boys). Out of the 170 eyes, 111 were myopic eyes and 59 were emmetropic. Myopic eyes had a significantly lower CH (p=0.001), CRF (p=0.002) and CCT (p=0.009), and higher AL (p<0.001) than emmetropic eyes. The AL and CCT were significantly higher in myopic males, compared to myopic females (p<0.001 and 0.001). In myopes, we found statistically significant negative correlations between AL and CH (Pearson's r=-0.218), CRF (r=-0.226) and also SE (r=-0.539), and positive between SE and either CH (r=0.193) or CRF (r=0.201).
Corneal biomechanical properties are significantly related to myopia parameters in children.
本研究旨在探讨近视儿童和青少年的角膜生物力学与眼形态之间的关系。
该研究纳入了 170 名右眼患者（年龄均在 18 岁以下），对其进行全面眼科检查，收集以下数据：等效球镜（在药物性睫状肌麻痹下）、生物力学参数——角膜滞后（CH）和角膜阻力因子（CRF）、结构参数——眼轴（AL）和中央角膜厚度（CCT）。
患者的平均年龄为 15.26 岁（55.29%为女性，44.70%为男性）。在这 170 只眼中，111 只为近视眼，59 只为正视眼。与正视眼相比，近视眼的 CH（p=0.001）、CRF（p=0.002）和 CCT（p=0.009）明显较低，而 AL（p<0.001）明显较高。与近视女性相比，近视男性的 AL 和 CCT 更高（p<0.001 和 0.001）。在近视患者中，我们发现 AL 与 CH（Pearson's r=-0.218）、CRF（r=-0.226）和 SE（r=-0.539）之间存在显著的负相关，SE 与 CH（r=0.193）或 CRF（r=0.201）之间存在显著的正相关。
儿童的角膜生物力学特性与近视参数显著相关。
