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一项评估原发性青光眼患者角膜内皮细胞密度和中央角膜厚度的横断面研究。

A cross sectional study on evaluating the corneal endothelial cell density and central corneal thickness in eyes with primary glaucoma.

作者信息

Sugumaran Asvini, Devasena Meera A, Thomas Mary, Periyathambi Dharssana

机构信息

Fellowship Resident in Arvind Eye Hospital, Chennai, Tamil Nadu, India.

Department of Ophthalmology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, Tamil Nadu, India.

出版信息

J Family Med Prim Care. 2022 Aug;11(8):4650-4654. doi: 10.4103/jfmpc.jfmpc_2423_21. Epub 2022 Aug 30.

DOI:10.4103/jfmpc.jfmpc_2423_21
PMID:36352928
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9638673/
Abstract

BACKGROUND

This study aims at evaluating glaucoma-induced damage to the corneal endothelium and the effect of central corneal thickness (CCT) on the intra-ocular pressure (IOP) measurement in patients newly diagnosed with primary glaucoma.

METHODS

It is a hospital-based cross-sectional study involving 60 newly diagnosed primary glaucoma patients >18 years. They underwent fundus examination, four-mirror gonioscopy, and perimetry for confirming the diagnosis. Evaluation and analysis of corneal endothelial cell density and CCT were performed. Chi square test was performed to find out the association between glaucoma, corneal endothelial cell density, and CCT.

RESULTS

Evaluation of 60 patients revealed that by age distribution, the corneal endothelial cell density was lower in the 51-65 year age group and an age-related decrease in corneal endothelial cell density and CCT was found in newly diagnosed primary glaucoma patients. The mean CCT was 525 micrometers in patients with IOP between 20 to 40 mm Hg and 528 micrometers in patients with IOP between 41 to 60 mm Hg. The mean corneal endothelial cell density was 2361 cells/mm in primary open-angle glaucoma (POAG) and 2284 cells/mm in primary angle-closure glaucoma (PACG). The mean CCT was 525 micrometers in POAG and 528 micrometers in PACG.

CONCLUSIONS

The corneal endothelial cell density was lower in patients with PACG when compared with POAG, and the average CCT showed no significant difference in POAG and PACG patients. However, CCT was increased in patients with a higher intra-ocular pressure. The corneal endothelial cell density was lower in patients with a high intra-ocular pressure.

摘要

背景

本研究旨在评估青光眼对角膜内皮的损害以及中央角膜厚度（CCT）对新诊断的原发性青光眼患者眼压（IOP）测量的影响。

方法

这是一项基于医院的横断面研究，纳入了60例年龄大于18岁的新诊断原发性青光眼患者。他们接受了眼底检查、四镜房角镜检查和视野检查以确诊。对角膜内皮细胞密度和CCT进行了评估和分析。采用卡方检验来找出青光眼、角膜内皮细胞密度和CCT之间的关联。

结果

对60例患者的评估显示，按年龄分布，51 - 65岁年龄组的角膜内皮细胞密度较低，且在新诊断的原发性青光眼患者中发现角膜内皮细胞密度和CCT与年龄相关下降。眼压在20至40 mmHg之间的患者平均CCT为525微米，眼压在41至60 mmHg之间的患者平均CCT为528微米。原发性开角型青光眼（POAG）患者的平均角膜内皮细胞密度为2361个细胞/mm，原发性闭角型青光眼（PACG）患者为2284个细胞/mm。POAG患者的平均CCT为525微米，PACG患者为528微米。

结论

与POAG患者相比，PACG患者的角膜内皮细胞密度较低，POAG和PACG患者的平均CCT无显著差异。然而，眼压较高的患者CCT升高。眼压较高的患者角膜内皮细胞密度较低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54d8/9638673/4dcebbf3ed05/JFMPC-11-4650-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54d8/9638673/418068ad39f8/JFMPC-11-4650-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54d8/9638673/dbca0919ca48/JFMPC-11-4650-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54d8/9638673/b485a525af71/JFMPC-11-4650-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54d8/9638673/cfe4b5b8bb1b/JFMPC-11-4650-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54d8/9638673/a848d2f4abff/JFMPC-11-4650-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54d8/9638673/4dcebbf3ed05/JFMPC-11-4650-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54d8/9638673/418068ad39f8/JFMPC-11-4650-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54d8/9638673/dbca0919ca48/JFMPC-11-4650-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54d8/9638673/b485a525af71/JFMPC-11-4650-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54d8/9638673/cfe4b5b8bb1b/JFMPC-11-4650-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54d8/9638673/a848d2f4abff/JFMPC-11-4650-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54d8/9638673/4dcebbf3ed05/JFMPC-11-4650-g006.jpg

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2
Corneal endothelial cell density and morphology in healthy Chinese eyes.健康中国人眼睛的角膜内皮细胞密度和形态
Cornea. 2007 Feb;26(2):130-2. doi: 10.1097/ICO.0b013e31802be63e.
3
Effect of a previous acute angle closure attack on the corneal endothelial cell density in chronic angle closure glaucoma patients.
既往急性闭角型青光眼发作对慢性闭角型青光眼患者角膜内皮细胞密度的影响。
J Glaucoma. 2006 Dec;15(6):482-5. doi: 10.1097/01.ijg.0000212273.73100.31.
4
The balance between corneal transparency and edema: the Proctor Lecture.角膜透明度与水肿之间的平衡：普罗克特讲座
Invest Ophthalmol Vis Sci. 2006 May;47(5):1754-67. doi: 10.1167/iovs.05-1139.
5
Central corneal thickness correlated with glaucoma damage and rate of progression.中央角膜厚度与青光眼损害及进展速率相关。
Invest Ophthalmol Vis Sci. 2005 Apr;46(4):1269-74. doi: 10.1167/iovs.04-0265.
6
Corneal endothelial status in the subtypes of primary angle closure glaucoma.原发性闭角型青光眼各亚型的角膜内皮状态
Clin Exp Ophthalmol. 2003 Dec;31(6):492-5. doi: 10.1046/j.1442-9071.2003.00710.x.
7
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Ophthalmology. 2001 Oct;108(10):1779-88. doi: 10.1016/s0161-6420(01)00760-6.
8
Corneal endothelial cell density and morphology in normal Indian eyes.正常印度人眼睛的角膜内皮细胞密度与形态
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10
Distribution of central corneal thickness and its association with intraocular pressure: The Rotterdam Study.中央角膜厚度的分布及其与眼压的关系：鹿特丹研究
Am J Ophthalmol. 1997 Jun;123(6):767-72. doi: 10.1016/s0002-9394(14)71125-0.