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高脂肪饮食加液体果糖喂养的雄性大鼠脂肪组织可预防肝脂肪变性：与性别相关的差异。

Adipose Tissue Protects against Hepatic Steatosis in Male Rats Fed a High-Fat Diet plus Liquid Fructose: Sex-Related Differences.

机构信息

Department of Pharmacology, Toxicology and Therapeutic Chemistry, School of Pharmacy and Food Science, University of Barcelona, 08028 Barcelona, Spain.

Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain.

出版信息

Nutrients. 2023 Sep 8;15(18):3909. doi: 10.3390/nu15183909.

DOI:10.3390/nu15183909
PMID:37764693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10534325/
Abstract

Non-alcoholic fatty liver disease is a sexual dimorphic disease, with adipose tissue playing an essential role. Our previous work showed that female rats fed a high-fat high-fructose diet devoid of cholesterol (HFHFr) developed simple hepatic steatosis dissociated from obesity. This study assessed the impact of the HFHFr diet on the male rat metabolism compared with data obtained for female rats. A total of 16 Sprague Dawley (SD) male rats were fed either a control (standard rodent chow and water) or HFHFr (high-fat diet devoid of cholesterol, plus 10% fructose in drinking water) diet for 3 months. Unlike female rats, and despite similar increases in energy consumption, HFHFr males showed increased adiposity and hyperleptinemia. The expression of hormone-sensitive lipase in the subcutaneous white adipose tissue was enhanced, leading to high free fatty acid and glycerol serum levels. HFHFr males presented hypertriglyceridemia, but not hepatic steatosis, partially due to enhanced liver PPARα-related fatty acid β-oxidation and the VLDL-promoting effect of leptin. In conclusion, the SD rats showed a sex-related dimorphic response to the HFHFr diet. Contrary to previous results for HFHFr female rats, the male rats were able to expand the adipose tissue, increase fatty acid catabolism, or export it as VLDL, avoiding liver lipid deposition.

摘要

非酒精性脂肪性肝病是一种性别二态性疾病，脂肪组织起着至关重要的作用。我们之前的工作表明，给予高脂肪高果糖饮食且不含胆固醇的雌性大鼠（HFHFr）发展为与肥胖分离的单纯性肝脂肪变性。本研究评估了 HFHFr 饮食对雄性大鼠代谢的影响，并与雌性大鼠的数据进行了比较。总共 16 只 Sprague Dawley（SD）雄性大鼠分别喂食对照（标准啮齿动物饲料和水）或 HFHFr（不含胆固醇的高脂肪饮食，加上饮用水中的 10%果糖）饮食 3 个月。与雌性大鼠不同，尽管能量消耗相似，HFHFr 雄性大鼠表现出肥胖和高瘦素血症增加。皮下白色脂肪组织中激素敏感脂肪酶的表达增强，导致游离脂肪酸和甘油血清水平升高。HFHFr 雄性大鼠表现出高甘油三酯血症，但没有肝脂肪变性，部分原因是肝脏 PPARα 相关脂肪酸β氧化增强和瘦素促进 VLDL 的作用。总之，SD 大鼠对 HFHFr 饮食表现出与性别相关的二态性反应。与之前 HFHFr 雌性大鼠的结果相反，雄性大鼠能够扩张脂肪组织，增加脂肪酸分解代谢，或将其作为 VLDL 输出，从而避免肝脏脂质沉积。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc8/10534325/d89fadf42443/nutrients-15-03909-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc8/10534325/82654796fce3/nutrients-15-03909-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc8/10534325/330c6eb32a37/nutrients-15-03909-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc8/10534325/ef34cd44df7d/nutrients-15-03909-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc8/10534325/d89fadf42443/nutrients-15-03909-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc8/10534325/82654796fce3/nutrients-15-03909-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc8/10534325/4db01ac76a4f/nutrients-15-03909-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc8/10534325/9094cb821cb7/nutrients-15-03909-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc8/10534325/ef94ab8e89a6/nutrients-15-03909-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc8/10534325/330c6eb32a37/nutrients-15-03909-g005.jpg
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