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一名接受胰腺-肾脏移植的免疫抑制患者因[具体病因未给出]导致的慢性腹泻

Chronic Diarrhea Due to in an Immunosuppressed Patient with a Pancreas-Kidney Transplant.

作者信息

Solís-Sánchez Pablo, Fernández-Martínez Marta, Rodrigo-Calabia Emilio, de Alegría-Puig Carlos Ruiz

机构信息

Internal Medicine Service, University Hospital Marqués de Valdecilla-IDIVAL, 39008 Santander, Spain.

Microbiology Service, University Hospital Marqués de Valdecilla-IDIVAL, 39008 Santander, Spain.

出版信息

Pathogens. 2023 Sep 11;12(9):1151. doi: 10.3390/pathogens12091151.

Abstract

The genus belongs to the family. A patient with a pancreas-kidney transplant had multiple episodes of abdominal sepsis after surgery. was isolated in the ascitic and biliary fluid drains. After discharge, the patient had several diarrhea episodes, and was isolated in four stool samples. We decided to test whether the one strain that we initially isolated in ascitic fluid was the same that appeared in the successive stool samples. Five isolates of were found in the patient. Identification was performed using the MALDI-TOF system and confirmed via multiplex PCR. The analysis of the REP-PCR fingerprint patterns showed one cluster and confirmed that all isolates were related. We also demonstrated the virulent character of this species associated with genes encoding different toxins (act, alt, ast, hlyA, and aerA). The virulence of this species is associated with the expression of genes that encode different toxins, structural proteins, and metal-associated proteins. This case report highlights the severity of this disease, especially in immunocompromised patients, and its adequate treatment.

摘要

该属属于 科。一名接受胰肾移植的患者术后发生多次腹部败血症。在腹水和胆汁引流液中分离出 。出院后,患者出现多次腹泻发作,在四份粪便样本中分离出 。我们决定测试我们最初在腹水中分离出的一个菌株是否与随后粪便样本中出现的菌株相同。在该患者中发现了五株 。使用基质辅助激光解吸电离飞行时间(MALDI-TOF)系统进行鉴定,并通过多重聚合酶链反应(PCR)进行确认。REP-PCR指纹图谱分析显示为一个聚类,并确认所有分离株均相关。我们还证明了该物种与编码不同毒素(act、alt、ast、hlyA和aerA)的基因相关的毒力特征。该物种的毒力与编码不同毒素、结构蛋白和金属相关蛋白的基因表达有关。本病例报告强调了这种疾病的严重性,尤其是在免疫功能低下的患者中,以及其适当的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c48/10536218/ec8fb4bdf17b/pathogens-12-01151-g001.jpg

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