Komrakova Marina, Schilling Arndt Friedrich, Lehmann Wolfgang, Vasilev Veselin, Georgieva Katerina, Gerginska Fanka, Boyadjiev Nikolay, Delchev Slavi
Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Goettingen, 37075 Goettingen, Germany.
Department of Physiology, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
Pharmaceuticals (Basel). 2023 Sep 5;16(9):1249. doi: 10.3390/ph16091249.
The effects of combination treatments using the selective androgen receptor modulators (SARMs) ostarine (OST) or ligandrol (LIG) with treadmill exercise (TE) were studied in healthy adult rats. Fifteen-week-old male Wistar rats were divided into groups ( = 10/group). Experiment 1 consisted of (1) Control group: sedentary rats receiving vehicle; (2) OST: sedentary rats receiving OST; (3) TE: training rats receiving vehicle; (4) OST + TE: training rats receiving OST. Experiment 2 consisted of (1) LIG: sedentary group receiving LIG; (2) LIG + TE: training group receiving LIG. The TE regime was as follows: 25 m/min, 5° elevation, 40 min, five times/week, and the sedentary regime was 5 min, three times/week. OST and LIG were administered subcutaneously (0.4 mg/kg body weight/day, five times/week). After eight weeks, bone samples underwent microcomputed tomographical, biomechanical, histological, and ashing analyses. All the treatments had weak effects on the bone structure without affecting bone biomechanics. The OST + TE improved bone structure, while the LIG + TE had unfavorable effects. In serum, OST, OST + TE, and LIG + TE altered cholesterol and lipoprotein levels; TE did not change the serum parameters. The SARM treatments had no clear bone benefit, and the serum effects can be considered as side effects. TE represents a safe treatment. Because SARMs are increasingly applied in gyms along with physical activities, attention should be paid to possible side effects.
在健康成年大鼠中研究了使用选择性雄激素受体调节剂（SARMs）奥司他丁（OST）或利加隆（LIG）与跑步机运动（TE）联合治疗的效果。将15周龄的雄性Wistar大鼠分成几组（每组n = 10）。实验1包括：（1）对照组：久坐不动的大鼠接受赋形剂；（2）OST组：久坐不动的大鼠接受OST；（3）TE组：训练大鼠接受赋形剂；（4）OST + TE组：训练大鼠接受OST。实验2包括：（1）LIG组：久坐组接受LIG；（2）LIG + TE组：训练组接受LIG。TE方案如下：速度25米/分钟，坡度5°，40分钟，每周5次，久坐方案为5分钟，每周3次。OST和LIG皮下给药（0.4毫克/千克体重/天，每周5次）。8周后，对骨样本进行显微计算机断层扫描、生物力学、组织学和灰化分析。所有治疗对骨结构的影响较弱，且不影响骨生物力学。OST + TE改善了骨结构，而LIG + TE有不利影响。在血清中，OST、OST + TE和LIG + TE改变了胆固醇和脂蛋白水平；TE未改变血清参数。SARM治疗对骨骼没有明显益处，血清效应可视为副作用。TE是一种安全的治疗方法。由于SARM越来越多地与体育活动一起在健身房中使用，应注意可能的副作用。
