Kim Dong Min, Baek Seung-Woon, Park Jeong Min, Kim Da-Seul, Lee Semi, Lee Jun-Kyu, Park Chun Gwon, Han Dong Keun
Department of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si 13488, Republic of Korea.
Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon-si 16419, Republic of Korea.
Pharmaceutics. 2023 Aug 28;15(9):2220. doi: 10.3390/pharmaceutics15092220.
As interest in skin aesthetics increases, treatments to suppress aging are increasing. Among them, a facelift is the most effective procedure for improving wrinkles. However, side effects including inflammatory reactions occur due to the limitations of the PDO thread itself used during the procedure. In this paper, to improve the function of PDO thread, inorganic particles such as magnesium hydroxide (MH) and zinc oxide (ZO) and a biologically active agent, asiaticoside, were coated on the surface of PDO thread using ultrasonic coating technology. The coated thread exhibited excellent biocompatibility, promoted collagen synthesis, reduced inflammation, and stimulated angiogenesis in vitro and in vivo. The multifunctional PDO thread has shown promising potential for skin regeneration without inducing fibrosis. Such a practical coating system and the developed multifunctional PDO thread suggest new possibilities for developing safer and more effective materials in cosmetic and regenerative medicine to prevent aging and improve skin aesthetics.
随着人们对皮肤美学的兴趣增加，抑制衰老的治疗方法也在增多。其中，面部提升术是改善皱纹最有效的方法。然而，由于手术过程中使用的聚对二氧环己酮（PDO）线本身存在局限性，会出现包括炎症反应在内的副作用。在本文中，为了改善PDO线的功能，使用超声涂层技术将氢氧化镁（MH）和氧化锌（ZO）等无机颗粒以及生物活性剂积雪草苷涂覆在PDO线表面。涂覆后的线在体外和体内均表现出优异的生物相容性，促进了胶原蛋白的合成，减轻了炎症，并刺激了血管生成。这种多功能PDO线在不诱导纤维化的情况下显示出皮肤再生的潜力。这样一种实用的涂层系统和开发的多功能PDO线为在美容和再生医学中开发更安全、更有效的材料以预防衰老和改善皮肤美学提供了新的可能性。
