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使用选择性激光烧结技术3D打印个性化卡维地洛片剂

3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering.

作者信息

Tabriz Atabak Ghanizadeh, Gonot-Munck Quentin, Baudoux Arnaud, Garg Vivek, Farnish Richard, Katsamenis Orestis L, Hui Ho-Wah, Boersen Nathan, Roberts Sandra, Jones John, Douroumis Dennis

机构信息

Delta Pharmaceutics Ltd., Chatham, Kent ME4 4TB, UK.

CRI Centre for Research Innovation, University of Greenwich, Chatham ME4 4TB, UK.

出版信息

Pharmaceutics. 2023 Aug 29;15(9):2230. doi: 10.3390/pharmaceutics15092230.

DOI:10.3390/pharmaceutics15092230
PMID:37765199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10537056/
Abstract

Selective laser sintering (SLS) has drawn attention for the fabrication of three-dimensional oral dosage forms due to the plurality of drug formulations that can be processed. The aim of this work was to employ SLS with a CO laser for the manufacturing of carvedilol personalised dosage forms of various strengths. Carvedilol (CVD) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon VA64) blends of various ratios were sintered to produce CVD tablets of 3.125, 6.25, and 12.5 mg. The tuning of the SLS processing laser intensity parameter improved printability and impacted the tablet hardness, friability, CVD dissolution rate, and the total amount of drug released. Physicochemical characterization showed the presence of CVD in the amorphous state. X-ray micro-CT analysis demonstrated that the applied CO intensity affected the total tablet porosity, which was reduced with increased laser intensity. The study demonstrated that SLS is a suitable technology for the development of personalised medicines that meet the required specifications and patient needs.

摘要

选择性激光烧结（SLS）因其能够处理多种药物制剂而在三维口服剂型的制造方面受到关注。这项工作的目的是使用二氧化碳激光的SLS技术来制造不同强度的卡维地洛个性化剂型。将不同比例的卡维地洛（CVD）和乙烯基吡咯烷酮-醋酸乙烯酯共聚物（聚乙烯吡咯烷酮VA64）混合物进行烧结，以生产3.125毫克、6.25毫克和12.5毫克的CVD片剂。SLS加工激光强度参数的调整改善了可印刷性，并影响了片剂硬度、脆碎度、CVD溶解速率和药物释放总量。物理化学表征表明存在非晶态的CVD。X射线显微CT分析表明，所施加的二氧化碳强度影响了片剂的总孔隙率，随着激光强度的增加孔隙率降低。该研究表明，SLS是一种适用于开发符合所需规格和患者需求的个性化药物的技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0d0/10537056/839551c9b824/pharmaceutics-15-02230-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0d0/10537056/9f78ebf9714c/pharmaceutics-15-02230-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0d0/10537056/bff4a18f31d5/pharmaceutics-15-02230-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0d0/10537056/95dc118da512/pharmaceutics-15-02230-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0d0/10537056/3b160c3f4d8f/pharmaceutics-15-02230-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0d0/10537056/751b30ec4e20/pharmaceutics-15-02230-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0d0/10537056/d373c79a2209/pharmaceutics-15-02230-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0d0/10537056/b35b21c5b90d/pharmaceutics-15-02230-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0d0/10537056/8db44a93e2fe/pharmaceutics-15-02230-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0d0/10537056/839551c9b824/pharmaceutics-15-02230-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0d0/10537056/9f78ebf9714c/pharmaceutics-15-02230-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0d0/10537056/bff4a18f31d5/pharmaceutics-15-02230-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0d0/10537056/95dc118da512/pharmaceutics-15-02230-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0d0/10537056/3b160c3f4d8f/pharmaceutics-15-02230-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0d0/10537056/751b30ec4e20/pharmaceutics-15-02230-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0d0/10537056/d373c79a2209/pharmaceutics-15-02230-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0d0/10537056/b35b21c5b90d/pharmaceutics-15-02230-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0d0/10537056/8db44a93e2fe/pharmaceutics-15-02230-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0d0/10537056/839551c9b824/pharmaceutics-15-02230-g009.jpg

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