Danysz W, Minor B G, Post C, Archer T
Acta Pharmacol Toxicol (Copenh). 1986 Aug;59(2):103-12. doi: 10.1111/j.1600-0773.1986.tb00141.x.
The effect of chronic and acute oral or intraperitoneal treatment with the antidepressant drugs, desipramine, amitriptyline, alaproclate and iprindole, upon pain thresholds in the tail flick, hot plate and shock titration tests of nociception in saline- and 5-MeODMT-treated rats was studied. Chronic desipramine treatment increased the pre-test tail flick latencies. In the saline-treated rats, chronic oral desipramine treatment increased tail flick latencies, whereas chronic oral amitriptyline treatment decreased tail flick latencies. In 5-MeODMT-treated rats, chronic oral desipramine treatment attenuated the effects of 5-MeODMT (1 mg/kg) in all three tests of nociception, whereas chronic amitriptyline caused a potentiation in the tail flick and hot plate tests. Chronic oral iprindole treatment attenuated 5-MeODMT-induced analgesia in the hot plate test. Chronic intraperitoneal desipramine treatment attenuated 5-MeODMT analgesia in the tail flick and shock titration tests. In a different chronic treatment experiment, oral desipramine treatment attenuated 5-MeODMT analgesia in the tail flick test and zimeldine did for both the tail flick and hot plate tests, whereas mianserin potentiated 5-MeODMT-induced analgesia in both the tail flick and hot plate tests. In the saline-treated rats, acute treatment with all four drugs, desipramine, amitriptyline, iprindole and alaproclate, elevated the shock thresholds, whereas in 5-MeODMT-treated rats, desipramine and amitriptyline elevated shock thresholds. Two main conclusions can be drawn: chronic desipramine caused a quite consistent attenuation of 5-MeODMT-induced analgesia and the effects of acute treatment differed strongly from that of the chronic treatment. The effects of chronic administration with these antidepressants were compared with other findings using different measures of behavioural and receptor function.
研究了用抗抑郁药去甲丙咪嗪、阿米替林、阿普氯胺和茚满二氮卓进行慢性和急性口服或腹腔注射治疗，对生理盐水处理和5 - 甲氧基 - N,N - 二甲基色胺（5 - MeODMT）处理的大鼠在甩尾、热板和伤害性刺激滴定试验中的痛阈的影响。慢性去甲丙咪嗪治疗增加了预试验甩尾潜伏期。在生理盐水处理的大鼠中，慢性口服去甲丙咪嗪治疗增加了甩尾潜伏期，而慢性口服阿米替林治疗则降低了甩尾潜伏期。在5 - MeODMT处理的大鼠中，慢性口服去甲丙咪嗪治疗在所有三项伤害感受试验中减弱了5 - MeODMT（1毫克/千克）的作用，而慢性阿米替林在甩尾和热板试验中导致了增强作用。慢性口服茚满二氮卓治疗在热板试验中减弱了5 - MeODMT诱导的镇痛作用。慢性腹腔注射去甲丙咪嗪治疗在甩尾和伤害性刺激滴定试验中减弱了5 - MeODMT镇痛作用。在另一个慢性治疗实验中，口服去甲丙咪嗪治疗在甩尾试验中减弱了5 - MeODMT镇痛作用，齐美利定在甩尾和热板试验中均有此作用，而米安色林在甩尾和热板试验中均增强了5 - MeODMT诱导的镇痛作用。在生理盐水处理的大鼠中，用去甲丙咪嗪、阿米替林、茚满二氮卓和阿普氯胺这四种药物进行急性治疗均提高了电击阈值，而在5 - MeODMT处理的大鼠中，去甲丙咪嗪和阿米替林提高了电击阈值。可以得出两个主要结论：慢性去甲丙咪嗪导致5 - MeODMT诱导的镇痛作用相当一致地减弱，并且急性治疗的效果与慢性治疗的效果有很大差异。将这些抗抑郁药的慢性给药效果与使用行为和受体功能的不同测量方法的其他研究结果进行了比较。
