元素在高血压病理生理学及抗高血压药物研发中的作用

Role of elements in pathophysiology of hypertension and antihypertensive drug development.

作者信息

Arora R B, Roy S, Khan S U

出版信息

Acta Pharmacol Toxicol (Copenh). 1986;59 Suppl 7:344-7. doi: 10.1111/j.1600-0773.1986.tb02776.x.

DOI:10.1111/j.1600-0773.1986.tb02776.x

Abstract

Cadmium and Zinc levels were determined in 100 patients of Essential hypertension by Atomic Absorption Spectrophotometer. It was shown that the mean levels of Serum cadmium were 43.34% +/- 6.5% higher and zinc were 28.42% +/- 5.4% lower in hypertensive when compared with normotensive controls. A statistically significant relationship between the height of diastolic blood pressure and Serum cadmium levels was observed. Ajmaloon a preparation from Rauvolfia serpentina with corrective herbs lowered the blood pressure effectively and significantly P less than 0.001. The side effects were minimal. It also tends to decrease the elevated serum cadmium levels in hypertensive individuals. A plea for development of Catecholamine depleting agents as drug for hypertension is advanced.

摘要

采用原子吸收分光光度计测定了100例原发性高血压患者的镉和锌水平。结果显示，与血压正常的对照组相比，高血压患者血清镉的平均水平高43.34%±6.5%，锌的平均水平低28.42%±5.4%。观察到舒张压高度与血清镉水平之间存在统计学上的显著关系。阿吉马隆是一种由蛇根木与矫正草药制成的制剂，能有效且显著地降低血压（P<0.001）。副作用极小。它还倾向于降低高血压个体中升高的血清镉水平。有人提出应研发儿茶酚胺耗竭剂作为治疗高血压的药物。