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长链非编码RNA DLX6-AS1/miR-16-5p轴调控非小细胞肺癌中的自噬和凋亡：细胞死亡的布尔模型

The lncRNA DLX6-AS1/miR-16-5p axis regulates autophagy and apoptosis in non-small cell lung cancer: A Boolean model of cell death.

作者信息

Gupta Shantanu, Silveira Daner A, Mombach José Carlos M, Hashimoto Ronaldo F

机构信息

Instituto de Matemática e Estatística, Departamento de Ciência da Computação, Universidade de São Paulo, Rua Do Matão 1010, São Paulo, SP, 05508-090, Brazil.

Children's Cancer Institute, Porto Alegre, Rio Grande do Sul, Brazil.

出版信息

Noncoding RNA Res. 2023 Aug 10;8(4):605-614. doi: 10.1016/j.ncrna.2023.08.003. eCollection 2023 Dec.

DOI:10.1016/j.ncrna.2023.08.003
PMID:37767112
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10520667/
Abstract

Long non-coding RNA (lncRNA) distal-less homeobox 6 antisense RNA 1 (DLX6-AS1) is elevated in a variety of cancers, including non-small cell lung cancer (NSCLC) and cervical cancer. Although it was found that the microRNA-16-5p (miR-16), which is known to regulate autophagy and apoptosis, had been downregulated in similar cancers. Recent research has shown that in tumors with similar characteristics, DLX6-AS1 acts as a sponge for miR-16 expression. However, the cell death-related molecular mechanism of the DLX6-AS1/miR-16 axis has yet to be investigated. Therefore, we propose a dynamic Boolean model to investigate gene regulation in cell death processes via the DLX6-AS1/miR-16 axis. We found the finest concordance when we compared our model to many experimental investigations including gain-of-function genes in NSCLC and cervical cancer. A unique positive circuit involving BMI1/ATM/miR-16 is also something we predict. Our results suggest that this circuit is essential for regulating autophagy and apoptosis under stress signals. Thus, our Boolean network enables an evident cell-death process coupled with NSCLC and cervical cancer. Therefore, our results suggest that DLX6-AS1 targeting may boost miR-16 activity and thereby restrict tumor growth in these cancers by triggering autophagy and apoptosis.

摘要

长链非编码RNA（lncRNA）远端同源盒6反义RNA 1（DLX6-AS1）在包括非小细胞肺癌（NSCLC）和宫颈癌在内的多种癌症中表达上调。尽管已知调节自噬和凋亡的微小RNA-16-5p（miR-16）在类似癌症中表达下调。最近的研究表明，在具有相似特征的肿瘤中，DLX6-AS1充当miR-16表达的海绵。然而，DLX6-AS1/miR-16轴与细胞死亡相关的分子机制尚未得到研究。因此，我们提出了一个动态布尔模型，以研究通过DLX6-AS1/miR-16轴在细胞死亡过程中的基因调控。当我们将模型与包括NSCLC和宫颈癌中功能获得性基因在内的许多实验研究进行比较时，发现了最佳的一致性。我们还预测了一个涉及BMI1/ATM/miR-16的独特正反馈回路。我们的结果表明，该回路在应激信号下对调节自噬和凋亡至关重要。因此，我们的布尔网络能够清晰地呈现与NSCLC和宫颈癌相关的细胞死亡过程。因此，我们的结果表明，靶向DLX6-AS1可能会增强miR-16的活性，从而通过触发自噬和凋亡来限制这些癌症中的肿瘤生长。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b8/10520667/e0874783433a/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b8/10520667/fbb9a0b1b2da/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b8/10520667/d7b88662cc1f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b8/10520667/a0aca29cf5a3/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b8/10520667/b1c0f8d44b83/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b8/10520667/470cf71061b8/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b8/10520667/329043a47aa7/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b8/10520667/e0874783433a/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b8/10520667/fbb9a0b1b2da/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b8/10520667/d7b88662cc1f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b8/10520667/a0aca29cf5a3/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b8/10520667/b1c0f8d44b83/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b8/10520667/470cf71061b8/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b8/10520667/329043a47aa7/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b8/10520667/e0874783433a/gr7.jpg

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2
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Cells. 2023 Apr 4;12(7):1085. doi: 10.3390/cells12071085.
3
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Int J Mol Sci. 2024 Jul 29;25(15):8264. doi: 10.3390/ijms25158264.
4
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6
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