Crimi N, Palermo F, Gibellino F, Vancheri C, Palermo B, Oliveri R, Mistretta A
Allergol Immunopathol (Madr). 1986 Jul-Aug;14(4):263-8.
The effect of nifedipine on allergen-induced asthma in nine asthmatic subjects was studied. All subjects had a history of asthma and positive Prick test; lyophilized allergen extracts of Dermatophagoides Pteronyssinus were used. All solutions were inhaled through DeVilbiss nebulizer. On the first day baseline FEV1 value was measured, allergen extracts were inhaled at increasing doses. The procedure was repeated until a 20% fall from the baseline FEV1 was obtained. Nifedipine or placebo capsules were administered sublingually in a randomized double blind manner. Antigen challenge was given 30 minutes later by using provocating dose of allergen. The change in FEV1 value was calculated from the post nifedipine administration. A significant negative correlation (p less than 0.01) was found between the percentage of protection and the baseline PD20. Nifedipine produced a significant mean change of the bronchial reactivity threshold (p less than 0.01).
研究了硝苯地平对9名哮喘患者变应原诱发哮喘的影响。所有受试者均有哮喘病史且点刺试验呈阳性；使用了尘螨变应原冻干提取物。所有溶液均通过德维比斯雾化器吸入。第一天测量基线第一秒用力呼气容积（FEV1）值，以递增剂量吸入变应原提取物。重复该操作，直至FEV1较基线下降20%。以随机双盲方式舌下给予硝苯地平或安慰剂胶囊。30分钟后使用激发剂量的变应原进行抗原激发。根据硝苯地平给药后的情况计算FEV1值的变化。在保护百分比与基线PD20之间发现显著的负相关（p<0.01）。硝苯地平使支气管反应性阈值产生显著的平均变化（p<0.01）。
