Molecular Sciences Lab, National Institute of Immunology New Delhi, Aruna Asaf Ali Marg, New Delhi, New Delhi, 110067, India.
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Mol Nutr Food Res. 2024 Jul;68(13):e2300104. doi: 10.1002/mnfr.202300104. Epub 2023 Sep 28.
The emerging role of gut microbiota and their metabolites in the modulation of the gut-brain axis has received much attention as a new hope for the treatment of hard-to-treat chronic neurodegenerative diseases like Alzheimer's disease. The naturally occurring polyphenols can restore the gut-brain axis by modulating gut microbiota and brain neurotransmitters. The Indian traditional medicine Triphala, a rich source of polyphenols, has been used on humans based on Prakriti or disease conditions for many years.
In this study, the dual mode (morning and evening) action of Triphala is used to provide scientific evidence of its superior preventive and therapeutic efficacy in C57BL/6 and 5xFAD, APP/PS1 transgenic mouse model of Alzheimer's disease. The study observes that Triphala treatment has significantly improved cognitive function, by modulating the APP pathway, reducing inflammation, and restoring the gut-brain axis by increasing the gut microbiota phyla of Bacteroides, Proteobacteria, Actinobacteria, etc., involved in maintaining the gut homeostasis.
The study paves a new path for using dual modes of Triphala alone or in combination to treat incurable AD.
肠道微生物群及其代谢物在调节肠脑轴中的新兴作用，作为治疗阿尔茨海默病等难以治疗的慢性神经退行性疾病的新希望，受到了广泛关注。天然存在的多酚可以通过调节肠道微生物群和大脑神经递质来恢复肠脑轴。印度传统药物 Triphala 是多酚的丰富来源，根据 Prakriti 或疾病状况，已经在人类身上使用了很多年。
在这项研究中，Triphala 的双重模式（早晚）作用被用于为其在 C57BL/6 和 5xFAD、APP/PS1 转基因阿尔茨海默病小鼠模型中的卓越预防和治疗功效提供科学证据。研究观察到 Triphala 治疗通过调节 APP 途径、减少炎症以及通过增加参与维持肠道内稳态的肠道微生物群门（如拟杆菌门、变形菌门和放线菌门）来显著改善认知功能。
该研究为单独使用或联合使用 Triphala 的双重模式治疗无法治愈的 AD 开辟了新途径。
