Department of Dermatology, Venereology and Leprology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Int J Dermatol. 2023 Dec;62(12):1447-1457. doi: 10.1111/ijd.16859. Epub 2023 Sep 28.
Acquired dermal macular hyperpigmentation (ADMH), previously known as macular pigmentation of uncertain etiology (MPUE), is an umbrella concept that unifies the distinct but overlapping acquired dermal pigmentary disorders like lichen planus pigmentosus, ashy dermatosis, erythema dyschromicum perstans, Riehl's melanosis and pigmented contact dermatitis. All of these disorders usually lack a clinically apparent inflammatory phase, are characterised by dermal pigmentation clinically and histologically, and have a variable protracted disease course. Recently, a proposal has been made to classify these disorders into those with and without contact sensitisation. Dermoscopy is essentially similar across the spectrum of these disorders, and is useful for diagnosis and therapeutic response monitoring. Scoring system has been validated for the same. The treatment of ADMH remains challenging, with multiple topicals, oral therapies including mycophenolate mofetil, and lasers tried. Need of the hour is randomised controlled trials to enhance the therapeutic armamentarium.
获得性皮肤黄斑色素沉着症(ADMH),以前称为不明病因性黄斑色素沉着症(MPUE),是一个统一概念,将不同但重叠的获得性皮肤色素沉着疾病如扁平苔藓色素沉着、灰泥皮炎、持久性色素性红斑、Riehl 黑变病和色素性接触性皮炎统一起来。所有这些疾病通常缺乏明显的临床炎症期,其特征是临床上和组织学上存在真皮色素沉着,并具有多变的迁延性疾病过程。最近,有人提出将这些疾病分为有和无接触致敏的两种类型。这些疾病的皮肤镜表现基本相似,对诊断和治疗反应监测都很有用。已经验证了针对这些疾病的评分系统。ADMH 的治疗仍然具有挑战性,已经尝试了多种局部治疗、口服治疗包括霉酚酸酯和激光。现在需要的是随机对照试验来增强治疗手段。