Wang Huai-Yu, Chen Xiang-Long, Wu Chun-Yan, Yang Dong-Sheng, Chen Ting, Wu An-Xin
National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, P.R. China.
Org Lett. 2023 Oct 6;25(39):7220-7224. doi: 10.1021/acs.orglett.3c02839. Epub 2023 Sep 28.
Herein, we disclose a straightforward approach to access transition-metal-free reductive -formylation of nitroarenes. This reaction integrates the dual role of rongalite, which acts as a reductant and a C1 building block concurrently. This provides an alternative method for the synthesis of -aryl formamides from nitroarenes, including the construction of a C-N bond. The utility of this protocol was demonstrated by scale-up synthesis and late-stage functionalizations of complex molecules.
在此，我们公开了一种实现硝基芳烃无过渡金属还原甲酰化的直接方法。该反应整合了雕白粉的双重作用，其同时充当还原剂和C1结构单元。这为从硝基芳烃合成芳基甲酰胺提供了一种替代方法，包括构建C-N键。该方案的实用性通过复杂分子的放大合成和后期官能团化得到了证明。
