Bilalis Panayiotis, Alrashoudi Abdulelah Α, Susapto Hepi H, Moretti Manola, Alshehri Salwa, Abdelrahman Sherin, Elsakran Amr, Hauser Charlotte A E
Laboratory for Nanomedicine, Biological & Environmental Science & Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
ACS Appl Mater Interfaces. 2023 Oct 11;15(40):46710-46720. doi: 10.1021/acsami.3c10726. Epub 2023 Sep 28.
Nature-inspired smart materials offer numerous advantages over environmental friendliness and efficiency. Emulating the excellent adhesive properties of mussels foot proteins, where the lysine is in close proximity with the 3,4-dihydroxy-l-phenylalanine (DOPA), we report the synthesis of a novel photocurable peptide-based adhesive consisting exclusively of these two amino acids. Our adhesive is a highly concentrated aqueous solution of a monomer, a cross-linker, and a photoinitiator. Lap-shear adhesion measurements on plastic and glass surfaces and comparison with different types of commercial adhesives showed that the adhesive strength of our glue is comparable when applied in air and superior when used underwater. No toxicity of our adhesive was observed when the cytocompatibility on human dermal fibroblast cells was assessed. Preliminary experiments with various tissues and coral fragments showed that our adhesive could be applied to wound healing and coral reef restoration. Given the convenience of the facile synthesis, biocompatibility, ease of application underwater, and high adhesive strength, we expect that our adhesive may find application, but not limited, to the biomedical and environmental field.
受自然启发的智能材料在环境友好性和效率方面具有诸多优势。模仿贻贝足蛋白的优异粘附特性，其中赖氨酸与3,4-二羟基-L-苯丙氨酸（DOPA）紧密相邻，我们报道了一种仅由这两种氨基酸组成的新型光固化肽基粘合剂的合成。我们的粘合剂是一种由单体、交联剂和光引发剂组成的高浓度水溶液。在塑料和玻璃表面进行的搭接剪切粘附力测量以及与不同类型商业粘合剂的比较表明，我们的胶水在空气中使用时的粘附强度相当，在水下使用时则更优异。在评估对人皮肤成纤维细胞的细胞相容性时，未观察到我们的粘合剂具有毒性。对各种组织和珊瑚碎片进行的初步实验表明，我们的粘合剂可用于伤口愈合和珊瑚礁修复。鉴于其合成简便、生物相容性好、易于在水下应用以及高粘附强度等优点，我们预计我们的粘合剂可能会在生物医学和环境领域等得到应用，但不限于这些领域。
