慢性苍白球局部场电位与儿童肌张力障碍症状有关。
Chronic Pallidal Local Field Potentials Are Associated With Dystonic Symptoms in Children.
机构信息
Neurosciences and Mental Health Program, the Hospital for Sick Children, Toronto, Ontario, Canada.
Division of Neurology and Neurosurgery, McGill University, McGill University Health Centre, Montreal, Quebec, Canada.
出版信息
Neuromodulation. 2024 Apr;27(3):551-556. doi: 10.1016/j.neurom.2023.08.003. Epub 2023 Sep 26.
BACKGROUND
Novel deep brain stimulation devices can record local field potentials (LFPs), which represent the synchronous synaptic activity of neuronal populations. The clinical relevance of LFPs in patients with dystonia remains unclear.
OBJECTIVES
We sought to determine whether chronic LFPs recorded from the globus pallidus internus (GPi) were associated with symptoms of dystonia in children.
MATERIALS AND METHODS
Ten patients with heterogeneous forms of dystonia (genetic and acquired) were implanted with neurostimulators that recorded LFP spectral snapshots. Spectra were compared across parent-reported asymptomatic and symptomatic periods, with daily narrowband data superimposed in 24 one-hour bins.
RESULTS
Spectral power increased during periods of registered dystonic symptoms: mean increase = 102%, CI: (76.7, 132). Circadian rhythms within the LFP narrowband time series correlated with dystonic symptoms: for delta/theta-waves, correlation = 0.33, CI: (0.18, 0.47) and for alpha waves, correlation = 0.27, CI: (0.14, 0.40).
CONCLUSIONS
LFP spectra recorded in the GPi indicate a circadian pattern and are associated with the manifestation of dystonic symptoms.
背景
新型深部脑刺激设备可以记录局部场电位（LFPs），代表神经元群体的同步突触活动。LFP 在肌张力障碍患者中的临床相关性尚不清楚。
目的
我们旨在确定从苍白球 internus（GPi）记录的慢性 LFPs 是否与儿童肌张力障碍的症状相关。
材料和方法
10 名患有不同类型肌张力障碍（遗传和获得性）的患者植入了记录 LFP 频谱快照的神经刺激器。在有症状和无症状期间，对频谱进行了比较，并在 24 个 1 小时的时间窗中叠加了每日窄带数据。
结果
LFP 窄带时间序列中的昼夜节律与肌张力障碍症状相关：delta/theta 波的平均增加 = 102%，CI：（76.7，132）。GPi 中记录的 LFPs 频谱表明存在昼夜节律模式，并且与肌张力障碍症状的表现相关。
结论
GPi 中记录的 LFPs 谱表明存在昼夜节律模式，并与肌张力障碍症状的表现相关。
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