Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA.
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Mail Stop M2-C200, Seattle, WA, 98109, USA.
AIDS Behav. 2024 May;28(5):1512-1521. doi: 10.1007/s10461-023-04175-0. Epub 2023 Sep 28.
To develop effective PrEP adherence interventions, it is important to understand the interplay between disclosure of pre-exposure prophalxis (PrEP) use, social support, and PrEP adherence. We leveraged the HPTN 082 study conducted among 451 adolescent girls and young women (AGYW) (ages 16 to 25 years, 2016 to 2019) in South Africa and Zimbabwe. Among the 349 who had month three disclosure and PrEP adherence data, 60% (n = 206) felt supported by adults, and 89% (n = 309) disclosed PrEP use to at least one person. PrEP disclosure was not associated with increased adherence, measured by intracellular tenofovir-diphosphate concentrations in dried blood spots. Women who reported having supportive adults, and disclosed to their parents, had higher adherence at 6 months with an increase of 177 fmol/punch (95% CI 12 to 343, t = 2.11, p = 0.04). PrEP interventions that help AGYW identify supportive relationships and effectively communicate the benefits of PrEP may improve PrEP adherence.Clinicaltrials.gov ID number: NCT02732730.
为了开发有效的 PrEP 依从性干预措施，了解暴露前预防（PrEP）使用的披露、社会支持与 PrEP 依从性之间的相互作用非常重要。我们利用 HPTN 082 研究，该研究在南非和津巴布韦的 451 名青少年女孩和年轻女性（年龄 16 至 25 岁，2016 至 2019 年）中进行。在有三个月披露和 PrEP 依从性数据的 349 名参与者中，60%（n=206）感到得到了成年人的支持，89%（n=309）向至少一个人透露了 PrEP 的使用情况。PrEP 披露与依从性增加无关，这是通过在干血斑中测量细胞内替诺福韦二磷酸浓度来衡量的。报告有支持性成年人且向父母透露 PrEP 使用情况的女性，在 6 个月时的依从性更高，增加了 177fmol/扎（95%CI 12 至 343，t=2.11，p=0.04）。帮助青少年识别支持性关系并有效传达 PrEP 益处的 PrEP 干预措施可能会提高 PrEP 依从性。临床试验注册编号：NCT02732730。
