Clinical Trial Center, Daejeon Korean Medicine Hospital of Daejeon University, 75 Daedeok-daero 176beon-gil, Seo- gu, Daejeon, 35235, Korea.
Department of Cardiology and Neurology of Korean Medicine, College of Korean Medicine, Daejeon University, Daejeon, Korea.
Genes Genomics. 2023 Dec;45(12):1475-1487. doi: 10.1007/s13258-023-01443-0. Epub 2023 Sep 28.
The biological clock allows an organism to anticipate periodic environmental changes and adjust its physiology and behavior accordingly.
This retrospective cross-sectional study examined circadian gene polymorphisms and clinical characteristics associated with insulin resistance (IR).
We analyzed data from 1,404 Korean adults aged 30 to 55 with no history of cancer and cardio-cerebrovascular disease. The population was classified according to sex and homeostasis model assessment of insulin resistance (HOMA-IR) values. Demographics, anthropometric and clinical characteristics, and single nucleotide polymorphisms (SNPs) were analyzed with respect to sex, age, and HOMA-IR values. We used association rule mining to identify sets of SNPs from circadian and metabolic sensing genes that may be associated with IR.
Among the subjects, 15.0% of 960 women and 24.3% of 444 men had HOMA-IR values above 2. Most of the parameters differed significantly between men and women, as well as between the groups with high and low insulin sensitivity. Body fat mass of the trunk, which was significantly higher in insulin-resistant groups, had a higher correlation with high sensitivity C-reactive protein and hemoglobin levels in women, and alanine aminotransferase and aspartate aminotransferase levels in men. Homozygous minor allele genotype sets of SNPs rs17031578 and rs228669 in the PER3 gene could be more frequently found among women with HOMA-IR values above 2 (p = .014).
Oxidative stress enhanced by adiposity and iron overload, which may also be linked to NRF2 and PER3-related pathways, is related to IR in adulthood. However, due to the small population size in this study, more research is needed.
生物钟使生物体能够预测周期性的环境变化，并相应地调整其生理和行为。
本回顾性横断面研究探讨了与胰岛素抵抗（IR）相关的昼夜节律基因多态性和临床特征。
我们分析了 1404 名年龄在 30 至 55 岁、无癌症和心脑血管疾病史的韩国成年人的数据。根据性别和稳态模型评估的胰岛素抵抗（HOMA-IR）值对人群进行分类。分析了人口统计学、人体测量学和临床特征以及单核苷酸多态性（SNP）与性别、年龄和 HOMA-IR 值的关系。我们使用关联规则挖掘来确定来自昼夜节律和代谢感应基因的与 IR 相关的 SNP 集合。
在研究对象中，960 名女性中有 15.0%，444 名男性中有 24.3%的 HOMA-IR 值高于 2。大多数参数在男性和女性之间以及胰岛素敏感性高和低的组之间存在显著差异。胰岛素抵抗组的躯干体脂肪量显著较高，与女性的高敏 C 反应蛋白和血红蛋白水平以及男性的丙氨酸氨基转移酶和天冬氨酸氨基转移酶水平相关性更高。PER3 基因中 rs17031578 和 rs228669 的 SNP 纯合子等位基因基因型在 HOMA-IR 值高于 2 的女性中更常见（p = .014）。
肥胖和铁过载增强的氧化应激，这也可能与 NRF2 和 PER3 相关途径有关，与成年期的 IR 有关。然而，由于本研究的人口规模较小，需要进一步研究。
