Department of Electronics & Telecommunication Engineering, Rajshahi University of Engineering & Technology, Rajshahi-6204, Bangladesh.
Drug Deliv Transl Res. 2024 Mar;14(3):812-825. doi: 10.1007/s13346-023-01438-0. Epub 2023 Sep 28.
Microneedle has made excellent contribution in the era of biomedical sector. This paper presents a reservoir-based out-of-plane silicon carbide (SiC) microneedle which has two lumens for delivering drug. The total height of the designed microneedle is 451 µm where the conical tip area is about 69.39 µm. The additional part of this microneedle is a reservoir which is trapezium in shape having a height of 150 µm. This work use COMSOL Multiphysics software for the structural analysis and Ansys Workbench software to investigate the fluid analysis. The flow analyses are performed by releasing drugs from the reservoir where different viscosity based sample drugs are included. Although reservoir-based microneedles are existing, however, there is no system to control the fluid in those microneedles. Thus, this work proposes a controllable microneedle which able to control the drug flow by using a valve. For both the case of valveless and with a valve, the drug velocities are determined. As paracetamol has highest viscosity among other drugs, it provides lowest velocities. Conversely, the flow of aspirin shows high velocity of 6.51E-2 m/s without a valve and 4.26E-2 m/s with a valve. To analyze the skin insertion performance, a skin model including six layers is designed. The simulation results ensure that the proposed microneedle can penetrate the human skin successfully with less stress and deformation.
微针在生物医学领域做出了卓越的贡献。本文提出了一种基于储液器的平面外碳化硅（SiC）微针，它有两个用于输送药物的管腔。设计的微针总高度为 451µm，其中圆锥形针尖区域约为 69.39µm。这种微针的附加部分是一个储液器，其形状为梯形，高度为 150µm。这项工作使用 COMSOL Multiphysics 软件进行结构分析，使用 Ansys Workbench 软件进行流体分析。通过从储液器中释放药物来进行流动分析，其中包括不同粘度的样品药物。尽管基于储液器的微针已经存在，但目前还没有系统可以控制这些微针中的流体。因此，这项工作提出了一种可控微针，它可以通过使用阀门来控制药物的流动。对于无阀和有阀两种情况，都确定了药物的流速。由于对乙酰氨基酚是所有药物中粘度最高的，因此它的流速最低。相反，阿司匹林的流速在没有阀门的情况下为 6.51E-2m/s，在有阀门的情况下为 4.26E-2m/s。为了分析皮肤插入性能，设计了一个包括六层的皮肤模型。模拟结果确保了所提出的微针可以成功地穿透人体皮肤，同时施加的压力和变形较小。
