Ribeiro Carina, Rocha Gustavo, Flôr-DE-Lima Filipa, Ferreras Cristina, Moita Rita, Silva Renato, Azevedo Inês
Department of Gynecology, Obstetrics and Pediatrics, Faculty of Medicine, University of Porto, Porto, Portugal.
Department of Neonatology, São João University Hospital Center, Porto, Portugal -
Minerva Pediatr (Torino). 2023 Sep 28. doi: 10.23736/S2724-5276.23.07336-6.
Recent studies suggest that some hematological parameters and ratios provided by blood count collected on the first day of life may be predictors for the development of retinopathy of prematurity (ROP). The aims of this study were to assess whether hematological parameters and ratios in blood count collected on the first day of life are associated with ROP.
Retrospective data collection from electronic clinical files of inborn preterm infants with a gestational age of less than 30 weeks delivered from January 2008 to December 2022, in a level III Neonatal Intensive Care Unit (NICU). We collected detailed clinical and demographic data on the mother, pregnancy, mode of delivery, resuscitation, in-hospital neonatal morbidity, pathological examination of the placenta, and hematological parameters and ratios provided by blood count collected on the first day of life. We compared neonates with or without ROP and performed a subgroup analysis on patients with ROP≥2.
We included 140 preterm infants with ophthalmic examination; 81(57.9%) developed ROP. The need for platelet transfusions (OR=5.28; 95% CI: 1.31-21.21; P=0.019) and bronchopulmonary dysplasia (BPD) (OR=5.12; 95% CI: 1.14-22.98; P=0.033) were independent risk factors for ROP. In the multivariate analysis, no associations were found between any of the hematological parameters or ratios studied and ROP.
In our study, hematological parameters and ratios on the first day of life were not associated with the development of ROP. However, thrombocytopenia that required platelet transfusions was associated with ROP development and severity.
近期研究表明，出生第一天血常规检测提供的一些血液学参数和比值可能是早产儿视网膜病变（ROP）发生的预测指标。本研究旨在评估出生第一天血常规检测中的血液学参数和比值是否与ROP相关。
回顾性收集2008年1月至2022年12月在三级新生儿重症监护病房（NICU）出生的胎龄小于30周的早产新生儿的电子临床病历数据。我们收集了母亲、妊娠、分娩方式、复苏、住院期间新生儿发病率、胎盘病理检查以及出生第一天血常规检测提供的详细临床和人口统计学数据。我们比较了发生或未发生ROP的新生儿，并对ROP≥2级的患者进行了亚组分析。
我们纳入了140例接受眼科检查的早产儿；其中81例（57.9%）发生了ROP。需要输注血小板（OR=5.28；95%CI：1.31-21.21；P=0.019）和支气管肺发育不良（BPD）（OR=5.12；95%CI：1.14-22.98；P=0.033）是ROP的独立危险因素。在多变量分析中，所研究的任何血液学参数或比值与ROP之间均未发现关联。
在我们的研究中，出生第一天的血液学参数和比值与ROP的发生无关。然而，需要输注血小板的血小板减少症与ROP的发生和严重程度相关。
