Bai Wen Hua, Gu Dan Feng, Dai Yun, Chen Yu Hong, Yang Zu Ming, Lu Li Jun
Department of Neonatology, Suzhou Municipal Hospital, Suzhou, China.
Front Pediatr. 2023 Feb 21;11:1055992. doi: 10.3389/fped.2023.1055992. eCollection 2023.
Retinopathy of prematurity (ROP) is a retinal vascular disease with a high incidence in premature infants and is a leading cause of childhood blindness worldwide. The purpose of our study was to analyze the association between the use of probiotics and retinopathy of prematurity.
This study retrospectively collected clinical data of premature infants with gestational age <32 weeks and birth weight <1500 g admitted to the neonatal intensive care unit from January 1, 2019 to December 31, 2021 in Suzhou Municipal Hospital, China. Demographic and clinical data of the inclusion population were collected. The outcome was the occurrence of ROP. The chi-square test was used to compare categorical variables, while the t-test and the nonparametric Mann-Whitney U rank-sum test were used for continuous variables. Univariate and multivariate logistic regression were used to analyze the relationship between probiotics and ROP.
A total of 443 preterm infants met the inclusion criteria, of which 264 didn't receive probiotics and 179 were supplemented with probiotics. There were 121 newborns with ROP in the included population. The results of univariate analysis showed that the preterm infants with and without probiotics were significantly different in the gestational age, the birth weight, the one-minute Apgar score, the oxygen inhalation time, the acceptance rate of invasive mechanical ventilation, the prevalence of bronchopulmonary dysplasia, ROP and severe intraventricular hemorrhage and periventricular leukomalacia ( < 0.05). Unadjusted univariate logistic regression model result showed that probiotics (OR 0.383, 95% CI 0.240∼0.611) were the factors affecting ROP in preterm infants ( < 0.01). Multivariate logistic regression result (OR 0.575, 95% CI 0.333∼0.994) was consistent with univariate analysis ( < 0.05).
This study showed that probiotic was associated with a reduced risk of ROP in preterm infants with gestational age of <32 weeks and birth weight of <1500 g, but more large-scale prospective studies are still needed.
早产儿视网膜病变（ROP）是一种在早产儿中发病率较高的视网膜血管疾病，是全球儿童失明的主要原因。我们研究的目的是分析益生菌的使用与早产儿视网膜病变之间的关联。
本研究回顾性收集了2019年1月1日至2021年12月31日在中国苏州市立医院新生儿重症监护病房收治的孕周<32周且出生体重<1500g的早产儿的临床资料。收集纳入人群的人口统计学和临床数据。结局指标是ROP的发生情况。采用卡方检验比较分类变量，采用t检验和非参数曼-惠特尼U秩和检验分析连续变量。采用单因素和多因素logistic回归分析益生菌与ROP之间的关系。
共有443例早产儿符合纳入标准，其中264例未接受益生菌治疗，179例补充了益生菌。纳入人群中有121例新生儿发生ROP。单因素分析结果显示，使用和未使用益生菌的早产儿在孕周、出生体重、1分钟阿氏评分、吸氧时间、有创机械通气接受率、支气管肺发育不良患病率、ROP以及重度脑室内出血和脑室周围白质软化症方面存在显著差异（<0.05）。未校正的单因素logistic回归模型结果显示，益生菌（OR 0.383，95%CI 0.240∼0.611）是影响早产儿ROP的因素（<0.01）。多因素logistic回归结果（OR 0.
