Vollmer Steven V, Selwyn Jason D, Despard Brecia A, Roesel Charles L
Department of Marine and Environmental Sciences, Northeastern University, 430 Nahant Road, Nahant, MA 01908, USA.
Science. 2023 Sep 29;381(6665):1451-1454. doi: 10.1126/science.adi3601. Epub 2023 Sep 28.
White band disease (WBD) has caused unprecedented declines in the Caribbean corals, which are now listed as critically endangered species. Highly disease-resistant genotypes exist, but the genetic underpinnings of disease resistance are not understood. Using transmission experiments, a newly assembled genome, and whole-genome resequencing of 76 genotypes from Florida and Panama, we identified 10 genomic regions and 73 single-nucleotide polymorphisms that are associated with disease resistance and that include functional protein-coding changes in four genes involved in coral immunity and pathogen detection. Polygenic scores calculated from 10 genomic loci indicate that genetic screens can detect disease resistance in wild and nursery stocks of across the Caribbean.
白带病（WBD）已导致加勒比珊瑚数量出现前所未有的下降，这些珊瑚如今被列为极度濒危物种。存在高度抗病的基因型，但抗病性的遗传基础尚不清楚。通过传播实验、新组装的基因组以及对来自佛罗里达和巴拿马的76个基因型进行全基因组重测序，我们确定了10个基因组区域和73个单核苷酸多态性，它们与抗病性相关，并且包括参与珊瑚免疫和病原体检测的四个基因中的功能性蛋白质编码变化。从10个基因组位点计算出的多基因分数表明，基因筛选可以检测加勒比地区野生和育苗种群中的抗病性
