A 特异性黏附素 Scf1 控制表面关联、定植和毒力。
A -specific adhesin, Scf1 governs surface association, colonization, and virulence.
机构信息
Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.
Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
出版信息
Science. 2023 Sep 29;381(6665):1461-1467. doi: 10.1126/science.adf8972. Epub 2023 Sep 28.
Abstract
is an emerging fungal pathogen responsible for health care-associated outbreaks that arise from persistent surface and skin colonization. We characterized the arsenal of adhesins used by and discovered an uncharacterized adhesin, Surface Colonization Factor (Scf1), and a conserved adhesin, Iff4109, that are essential for the colonization of inert surfaces and mammalian hosts. is apparently specific to , and its expression mediates adhesion to inert and biological surfaces across isolates from all five clades. Unlike canonical fungal adhesins, which function through hydrophobic interactions, Scf1 relies on exposed cationic residues for surface association. is required for biofilm formation, skin colonization, virulence in systemic infection, and colonization of inserted medical devices.
摘要
是一种新兴的真菌病原体，可导致与医疗保健相关的爆发，这些爆发源于持续的表面和皮肤定植。我们对 使用的粘附素库进行了特征描述，并发现了一种未被描述的粘附素，表面定植因子（Scf1）和一种保守的粘附素，Iff4109，它们对于惰性表面和哺乳动物宿主的定植是必不可少的。显然是专门针对 的，其表达介导了对所有五个谱系的分离株的惰性和生物表面的粘附。与经典的真菌粘附素不同，后者通过疏水相互作用发挥作用，Scf1 依赖于暴露的阳离子残基进行表面结合。对于生物膜形成、皮肤定植、全身性感染的毒力以及插入式医疗设备的定植都是必需的。
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