Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Clin Invest Med. 2023 Sep 28;46(3):E19-33. doi: 10.25011/cim.v46i3.40760.
BACKGROUND: Stroke is a major contributor to disability and death worldwide. Studies have demonstrated that inflammasome/pyroptosis and its mediated inflammatory response are important factors aggravating brain injury after stroke. We aimed to investigate and map the knowledge structure and global trends on inflam- masome/pyroptosis in stroke. METHODS: All relevant documents were obtained from the Web of Science on 5 June 2023. Bibliometric visualization diagrams were created using VOSviewer and CiteSpace. Excel was used for statistical analysis and drawing graphs. RESULTS: A total of 1106 publications were included, with more articles published each year, especially since 2014. China (740 papers), Zhejiang University (57 papers), Wang J (25 papers), and the Journal of Neuroinflammation (45 papers) were the most productive countries, institutions, authors, and journals, respectively. The United States was the country with highest centrality (0.56) and total link strength (171), and all of the top 10 institutions were in China. China and the U.S. cooperated closely. The centralities of the top 10 authors were all lower than 0.01; no leader has yet emerged in this field. "NLRP3 inflammasome" ranked first with 447 occurrences among 2136 keywords, of which 56 terms appeared more than 10 times when categorized into four clusters: cluster 1 (inflammation), cluster 2 (pyroptosis), cluster 3 (NLRP3 inflammasome), and cluster 4 (neuroinflammation). The studies focused on the mechanisms of inflammasome/pyroptosis in stroke were mainly limited to cell and animal experiments. CONCLUSION: Interest in inflammasome/pyroptosis in stroke is progressively increasing. The NLRP3 inflammasome is the most extensively studied and has been a research hotspot. The mechanisms of cell death in stroke are complex and future studies are needed to strengthen the clinical research on the relationship between pyroptosis-related processes and stroke, determine at which stage NLRP3 inflammasome activation, and clarify the detailed mechanism of NLRP3 in stroke.
背景：中风是全球范围内导致残疾和死亡的主要原因。研究表明，炎症小体/细胞焦亡及其介导的炎症反应是加重中风后脑损伤的重要因素。我们旨在调查和绘制中风中炎症小体/细胞焦亡的知识结构和全球趋势。
方法：于 2023 年 6 月 5 日从 Web of Science 上获取所有相关文献。使用 VOSviewer 和 CiteSpace 创建文献计量可视化图谱。使用 Excel 进行统计分析和绘制图形。
结果：共纳入 1106 篇文献，每年发表的文章数量不断增加，尤其是自 2014 年以来。中国（740 篇论文）、浙江大学（57 篇论文）、Wang J（25 篇论文）和《神经炎症杂志》（45 篇论文）分别是发文量最多的国家、机构、作者和期刊。美国是中心度（0.56）和总链接强度（171）最高的国家，前 10 名机构均来自中国。中国和美国合作密切。前 10 名作者的中心度均低于 0.01；该领域尚未出现领军人物。在 2136 个关键词中，“NLRP3 炎症小体”出现了 447 次，在分为四个聚类的 56 个术语中，有 10 次以上出现的术语有 56 个：聚类 1（炎症）、聚类 2（细胞焦亡）、聚类 3（NLRP3 炎症小体）和聚类 4（神经炎症）。研究重点是炎症小体/细胞焦亡在中风中的机制，主要限于细胞和动物实验。
结论：中风中炎症小体/细胞焦亡的研究兴趣日益增加。NLRP3 炎症小体是研究最多的，也是研究热点。中风中细胞死亡的机制复杂，需要进一步的研究来加强对细胞焦亡相关过程与中风关系的临床研究，确定 NLRP3 炎症小体激活的阶段，并阐明 NLRP3 在中风中的详细机制。
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