对肺部疾病中细胞焦亡相关研究的全球趋势进行文献计量分析。

BACKGROUND: Pyroptosis is a lytic pro-inflammatory programmed cell death mode that depends on caspase, inflammasome, and Gasdermin D (GSDMD). A growing number of studies have shown that pyroptosis is closely related to the pathophysiological mechanism of lung. The purpose of this study is to analyze the literature from Science Citation Index Expanded (SCI-expanded) of Web of Science Core Collection (WoSCC) and visualize the current trends and hotspots in the research of pyroptosis in lung disease. METHODS: On February 20, 2022, we retrieved all articles on pyroptosis in lung disease from SCI-expanded of WoSCC. Original articles and reviews published in English from 2007 to 2021 were included in the analysis. VOSviewer 1.6.17 and CiteSpace 5.8.R2 were used to analyze the retrieved data and visualize the results. RESULT: 1798 qualified original articles and reviews on pyroptosis in lung disease were included in the bibliometric analysis. So far, the research in this field is still in a period of growth, and the number of global publications has increased yearly. Among the 66 countries that have published relevant articles, China ranked first in the number of publications, and the USA ranked first in the number of cited articles. Holian,A. was the author with the largest number of articles, including 21 published. The University of California System in the USA was the organization with the largest number of articles, totaling 55. Frontiers in Immunology was the journal with the most publications in pyroptosis. After bibliometric analysis, the frequently used keywords are: "NOD-like receptor3 (NLRP3) inflammasome", "inflammation", "oxidative stress", and "acute lung injury (ALI)". CONCLUSION: The research on pyroptosis in lung disease is in its growth stage. The information released in this article may help researchers better understand the hotspots and developmental trends in this field, the cooperation network information of authors, countries, and institutions, and the citation correlation between articles. With the in-depth study of the mechanism of pyroptosis, the focus has shifted to increasing research on the connections and influences of different diseases. So far, increasing attention has been paid to the research field of the relationship between ALI and pyroptosis related to COVID-19.

背景：细胞焦亡是一种依赖于半胱天冬酶、炎性小体和 Gasdermin D（GSDMD）的溶酶体炎性程序性细胞死亡方式。越来越多的研究表明，细胞焦亡与肺部的病理生理机制密切相关。本研究旨在通过分析来自科学引文索引扩展版（SCI-expanded）的文献，可视化肺部疾病中细胞焦亡研究的当前趋势和热点。

方法：2022 年 2 月 20 日，我们从 Web of Science 核心合集（WoSCC）的 SCI-expanded 中检索了所有关于肺部疾病中细胞焦亡的文章。纳入分析的原始文章和综述均为 2007 年至 2021 年发表的英文文章。使用 VOSviewer 1.6.17 和 CiteSpace 5.8.R2 分析检索数据并可视化结果。

结果：对纳入文献计量学分析的 1798 篇关于肺部疾病中细胞焦亡的原始文章和综述进行了分析。到目前为止，该领域的研究仍处于增长阶段，全球出版物数量逐年增加。在发表相关文章的 66 个国家中，中国发表的文章数量最多，美国发表的文章被引数量最多。作者发文数量最多的是 Holian,A.，共发表了 21 篇文章。发表文章数量最多的机构是美国加利福尼亚大学系统，总计 55 篇。发表细胞焦亡相关文章最多的期刊是 Frontiers in Immunology。经过文献计量分析，常用的关键词是：“NOD 样受体 3（NLRP3）炎性小体”、“炎症”、“氧化应激”和“急性肺损伤（ALI）”。

结论：肺部疾病中细胞焦亡的研究处于增长阶段。本文发布的信息可能有助于研究人员更好地了解该领域的热点和发展趋势、作者、国家和机构的合作网络信息以及文章之间的引文相关性。随着细胞焦亡机制的深入研究，研究重点已转移到增加对不同疾病之间联系和影响的研究。到目前为止，人们越来越关注与 COVID-19 相关的 ALI 与细胞焦亡相关的研究领域。