Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Front Immunol. 2021 Aug 18;12:731933. doi: 10.3389/fimmu.2021.731933. eCollection 2021.
Pyroptosis is a new programmed cell death discovered in recent years. Pyroptosis plays an important role in various diseases. Nevertheless, there are few bibliometric analysis systematically studies this field. We aimed to visualize the research hotspots and trends of pyroptosis using a bibliometric analysis to help understand the future development of basic and clinical research.
The articles and reviews regarding pyroptosis were culled from Web of Science Core Collection. Countries, institutions, authors, references and keywords in this field were visually analyzed by using CtieSpace and VOSviewer software.
A total of 2845 articles and reviews were included. The number of articles regarding pyroptosis significantly increased yearly. These publications mainly come from 70 countries led by China and the USA and 418 institutions. We identified 605 authors, among which Thirumaladevi Kanneganti had the most significant number of articles, and Shi JJ was co-cited most often. was the journal with the most studies, and was the most commonly cited journal. After analysis, the most common keywords are nod like receptor family pyrin domain containing 3 inflammasome, apoptosis, cell death, gasdermin D, mechanism, caspase-1, and others are current and developing areas of study.
Research on the pyroptosis is flourishing. Cooperation and exchanges between countries and institutions must be strengthened in the future. The related pathway mechanism of pyroptosis, the relationship between pyroptosis and other types of programmed cell deaths as well as the role of pyroptosis in various diseases have been the focus of current research and developmental trends in the future research.
细胞焦亡是近年来新发现的一种程序性细胞死亡方式。细胞焦亡在多种疾病中发挥重要作用。然而，目前很少有文献计量学分析系统地研究这个领域。我们旨在通过文献计量学分析来可视化细胞焦亡的研究热点和趋势，以帮助了解基础和临床研究的未来发展。
从 Web of Science 核心合集数据库中筛选有关细胞焦亡的文章和综述。使用 Citespace 和 Vosviewer 软件对该领域的国家、机构、作者、参考文献和关键词进行可视化分析。
共纳入 2845 篇文章和综述。关于细胞焦亡的文章数量呈逐年显著增加趋势。这些出版物主要来自中国和美国领衔的 70 个国家和 418 个机构。我们确定了 605 位作者，其中 Thirumaladevi Kanneganti 的文章数量最多，Shi JJ 的被引频次最高。《Cell》杂志发表的关于细胞焦亡的研究最多，《Nature》杂志的被引频次最高。经过分析，最常见的关键词是 NOD 样受体家族含 pyrin 结构域蛋白 3 炎性小体、细胞凋亡、细胞死亡、gasdermin D、机制、半胱氨酸天冬氨酸蛋白酶-1 等，其他关键词则是当前和未来的研究热点。
细胞焦亡的研究正在蓬勃发展。未来必须加强国家和机构之间的合作与交流。细胞焦亡的相关通路机制、细胞焦亡与其他类型程序性细胞死亡的关系以及细胞焦亡在各种疾病中的作用是当前研究的重点和未来研究的发展趋势。
