Teixeira Francisca S, Pimentel Lígia L, Pintado Manuela E, Rodríguez-Alcalá Luís M
Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005, Porto, Portugal.
Biochimie. 2023 Dec;215:69-74. doi: 10.1016/j.biochi.2023.09.020. Epub 2023 Sep 27.
The liver plays a crucial role in lipid metabolism and metabolic homeostasis. Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common chronic liver disease worldwide and currently has no specific treatments. Lifestyle modifications such as weight loss, exercise, and dietary changes are recommended to reduce the risk factors associated with the disease. Oxidized cholesterol products, some phospholipids and diacylglycerols can activate inflammatory pathways and contribute to the progression to Non-Alcoholic Steatohepatitis. Monitoring the whole plasma and liver lipidome may provide insights into the onset, development, and prevention of inflammatory-related diseases. As Lipid Droplets (LDs) represent augmented lipid reservoirs in NAFLD, new developments are being made on different therapies focused on LD associated proteins modulation (seipin, PLIN-2), as well as LD lipophagy mechanisms. The information covered in this publication provides an overview of the available research on lipid biomarkers linked to NAFLD and can be used to guide the development of future pharmacological therapies.
肝脏在脂质代谢和代谢稳态中起着至关重要的作用。非酒精性脂肪性肝病（NAFLD）是全球最常见的慢性肝病，目前尚无特效治疗方法。建议通过减肥、运动和饮食改变等生活方式调整来降低与该疾病相关的风险因素。氧化胆固醇产物、一些磷脂和二酰基甘油可激活炎症途径，并促进向非酒精性脂肪性肝炎的进展。监测全血浆和肝脏脂质组可能有助于深入了解炎症相关疾病的发病、发展和预防。由于脂滴（LDs）在NAFLD中代表增加的脂质储存库，目前正在针对专注于调节与LD相关蛋白（seipin、PLIN-2）以及LD自噬机制的不同疗法开展新的研究。本出版物涵盖的信息概述了与NAFLD相关的脂质生物标志物的现有研究，可用于指导未来药物治疗的开发。
