Centre de recherche Epidémiologie, Biostatistique et Recherche Clinique, Ecole de santé publique, Université libre de Bruxelles (U.L.B.), Bruxelles, Belgium.
Competence Center for Methodology and Statistics, Luxembourg Institute of Health, Strassen, Luxembourg.
Pharmacoepidemiol Drug Saf. 2024 Jan;33(1):e5705. doi: 10.1002/pds.5705. Epub 2023 Sep 28.
This study aimed to describe the implementation of a new retrospective Belgian national cohort of pregnant women, the Belgian Medication Exposure during Pregnancy (BeMeP).
We linked the national dispensing data to birth and death certificates and hospital stay data for a 7-year period between 2010 and 2016 for the first time in Belgium. We presented the characteristics of pregnancy events associated with the mothers enrolled in the linkage study. Next, we constructed a cohort of pregnancies and compared some characteristics computed using the BeMeP database with the national statistics. Finally, we described the use of medications during pregnancy based on the first level of the Anatomical Therapeutic Chemical (ATC) classification.
We included 630 457 pregnant women with 900 024 pregnancy-related events (843 780 livebirths, 1937 stillbirths, 6402 ectopic events, and 47 905 abortions) linked to medication exposure information. Overall, 96.3% of live births and 83.5% of stillbirths (national statistics as reference) were captured from the BeMeP. During pregnancy, excluding the week of birth, 78.9% of live birth pregnancies and 79.6% of stillbirth pregnancies were exposed to at least one medication. The most frequently dispensed medications were anti-infectives (ATC code J = 50.2%) for live births and for stillbirths (44.0%).
We linked information on pregnancies, all reimbursed medications dispensed by community pharmacists, all medications dispensed during hospitalization, sociodemographic status, and infant health to create the BeMeP database. The database represents a valuable potential resource for studying exposure-outcome associations for medication use during pregnancy.
本研究旨在描述一个新的比利时全国孕妇回顾性队列（BeMeP）的实施情况。
我们首次将国家配药数据与出生和死亡证明以及 2010 年至 2016 年 7 年期间的住院数据相链接。我们介绍了与参与链接研究的母亲相关的妊娠事件的特征。接下来，我们构建了一个妊娠队列，并比较了使用 BeMeP 数据库计算的一些特征与国家统计数据。最后，我们根据解剖治疗化学（ATC）分类的第一级描述了妊娠期间药物的使用情况。
我们纳入了 630457 名孕妇，其中有 900024 例与妊娠相关的事件（843780 例活产、1937 例死产、6402 例异位妊娠和 47905 例流产）与药物暴露信息相关联。总体而言，BeMeP 捕获了 96.3%的活产和 83.5%的死产（以国家统计数据为参考）。在妊娠期间，排除分娩周，78.9%的活产妊娠和 79.6%的死产妊娠至少暴露于一种药物。最常配给的药物是抗感染药（ATC 代码 J=50.2%），用于活产和死产（44.0%）。
我们将妊娠信息、社区药剂师配给的所有报销药物、住院期间配给的所有药物、社会人口统计学状况和婴儿健康信息链接起来，创建了 BeMeP 数据库。该数据库代表了一个有价值的潜在资源，可用于研究妊娠期间药物使用的暴露-结局关联。
