Centre de recherche Epidémiologie, Biostatistiques, Recherche Clinique, School of Public Health, Université Libre de Bruxelles (U.L.B.), Bruxelles, Belgium.
Agence Intermutualiste (IMA), Bruxelles, Belgium.
Pharmacoepidemiol Drug Saf. 2021 Sep;30(9):1224-1232. doi: 10.1002/pds.5299. Epub 2021 Jun 9.
The aim of this study was to describe trends in medication prescriptions dispensed during pregnancy in Belgium using administrative healthcare database records from a representative sample of the Belgian population.
Pregnant women were identified with reimbursement codes associated with the delivery of a baby. Data were extracted for three study periods, each over 3 years: 2003-2005, 2009-2011, and 2015-2017. The age-standardized prevalence of dispensed medications during pregnancy were computed and logistic regression models were used to evaluate the trends in prevalence across the study periods. The most frequently dispensed medications were listed for each study period.
The study included 23 912 pregnancies. The age-standardized prevalence of pregnant women with at least one dispensed medication increased across the three study periods from 81.8.% to 89.3%. The median number and interquartile range of the different medications dispensed during pregnancy rose from 2 (1-6) to 3 (1-7) between the first and last study periods. In the 2015-2017 period, the most frequently dispensed medications during pregnancy included progesterone (25.5%), paracetamol (17.8%), and amoxicillin (17.1%). The data also showed an increasing trend for the dispensation of ibuprofen and ketorolac during pregnancy across the three study periods.
The prevalence of prescribed medications dispensed during pregnancy increased in Belgium from 2003 to 2017 with high proportion for Progesterone and Antibiotics. Utilization of certain nonsteroidal anti-inflammatory drugs (NSAIDs) increased between 2003 and 2017, despite recommendations to avoid them.
本研究旨在使用比利时代表性人群的医疗保健管理数据库记录，描述比利时孕妇在怀孕期间的用药情况趋势。
通过与分娩相关的报销代码来确定孕妇。从三个研究期提取数据，每个研究期超过 3 年：2003-2005 年、2009-2011 年和 2015-2017 年。计算了怀孕期间配药的标准化患病率，并使用逻辑回归模型评估了研究期间的患病率趋势。列出了每个研究期间最常配药的药物。
研究纳入了 23912 例妊娠。三个研究期间，至少有一种药物配药的孕妇的标准化患病率从 81.8%增加到 89.3%。怀孕期间配药的不同药物中位数和四分位距从第一个研究期到最后一个研究期从 2（1-6）增加到 3（1-7）。在 2015-2017 年期间，怀孕期间最常配药的药物包括孕激素（25.5%）、扑热息痛（17.8%）和阿莫西林（17.1%）。数据还显示，在三个研究期间，怀孕期间布洛芬和酮咯酸的配药呈上升趋势。
2003 年至 2017 年期间，比利时孕妇配药的患病率增加，其中孕激素和抗生素的比例很高。尽管有避免使用某些非甾体抗炎药（NSAIDs）的建议，但在 2003 年至 2017 年期间，它们的使用有所增加。
