The Royal (Dick) School of Veterinary Studies & The Roslin Institute, The University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.
PDSA, Whitechapel Way, Priorslee, Telford, Shropshire, TF2 9PQ, UK.
J Small Anim Pract. 2023 Nov;64(11):687-695. doi: 10.1111/jsap.13671. Epub 2023 Sep 28.
To investigate the association between body mass and hypotension during general anaesthesia in dogs undergoing surgical and diagnostic procedures within a referral hospital.
Retrospective evaluation of the anaesthetic records of 1789 dogs was performed. Data on signalment, anaesthetic protocol and physiological variables, including mean arterial pressure, were collected. A multivariable generalised linear model was used to identify associations between explanatory variables, including body mass, and hypotension.
In the population studied, increasing body mass (per 10 kg) was significantly associated with decreasing odds of hypotension (odds ratio 0.68; 95% confidence interval: 0.60 to 0.77). Additional variables associated with a decreased odds of hypotension were pre-anaesthetic medication with alpha-2 agonists (odds ratio 0.63; 95% confidence interval 0.48 to 0.82) and increased body temperature (per 1°C) during general anaesthesia (odds ratio 0.77; 95% confidence interval 0.67 to 0.88). Brachycephaly (odds ratio 1.72; 95% confidence interval 1.25 to 2.38), ASA physical status classification >3 (odds ratio 2.03; 95% confidence interval 1.16 to 3.56), undergoing a surgical procedure (versus diagnostic) (odds ratio 1.57; 95% confidence interval 1.10 to 2.23) and bradycardia (odds ratio 1.37; 95% confidence interval 1.05 to 1.80) were independently associated with increased odds of hypotension.
Dogs of lower body mass and brachycephalic breeds may be at higher risk of hypotension during general anaesthesia or alternatively represent subpopulations in which accurate blood pressure measurement presents a greater challenge. Monitoring blood pressure accurately in these groups requires particular attention and provisions for treating hypotension should be readily accessible.
调查在转诊医院接受手术和诊断程序的狗在全身麻醉期间体重与低血压之间的关系。
对 1789 只狗的麻醉记录进行回顾性评估。收集了关于特征、麻醉方案和生理变量的数据，包括平均动脉压。使用多变量广义线性模型来确定包括体重在内的解释变量与低血压之间的关联。
在所研究的人群中，体重增加（每 10kg）与低血压的几率降低显著相关（比值比 0.68；95%置信区间：0.60 至 0.77）。与低血压几率降低相关的其他变量包括术前使用 α-2 激动剂（比值比 0.63；95%置信区间 0.48 至 0.82）和全身麻醉期间体温升高（每 1°C）（比值比 0.77；95%置信区间 0.67 至 0.88）。短头畸形（比值比 1.72；95%置信区间 1.25 至 2.38）、ASA 身体状况分类 >3（比值比 2.03；95%置信区间 1.16 至 3.56）、手术（与诊断相比）（比值比 1.57；95%置信区间 1.10 至 2.23）和心动过缓（比值比 1.37；95%置信区间 1.05 至 1.80）与低血压几率增加独立相关。
体重较低的狗和短头犬种在全身麻醉期间可能有更高的低血压风险，或者代表血压测量更具挑战性的亚人群。在这些群体中准确监测血压需要特别注意，并且应该随时准备好治疗低血压的措施。
