Center for Microbiology and Phage Therapy, Zewail City of Science and Technology, October Gardens, 6th of October City, Giza, Egypt.
Department of Biomedical Engineering, Sethu Institute of Technology, Virudhunagar, Tamil Nadu, India.
Prog Mol Biol Transl Sci. 2023;201:119-132. doi: 10.1016/bs.pmbts.2023.03.013. Epub 2023 Apr 10.
Bacteriophages (Phages in short) were introduced as the natural enemy of bacteria that may act as alternatives to antibiotics to overcome the challenge of antibiotic resistance. However, in the recent history of science, phages have been employed in different molecular tools and used in numerous therapeutic and diagnostic approaches. Furthermore, thanks to the phage`s highly specific host range limited to prokaryotes, phage particles can be used as safe delivery vehicles and display systems. In this chapter, different phage display systems are introduced, in addition to various applications of phage display as a molecular and therapeutic tool in developing vaccines, antibacterial, and anti-cancer treatments.
噬菌体(简称 Phage)被引入作为细菌的天敌,可以作为抗生素的替代品,以克服抗生素耐药性的挑战。然而,在科学的近代史上,噬菌体已被用于不同的分子工具,并应用于许多治疗和诊断方法。此外,由于噬菌体的宿主范围非常特异,仅限于原核生物,噬菌体颗粒可以用作安全的输送载体和展示系统。在本章中,介绍了不同的噬菌体展示系统,以及噬菌体展示作为一种分子和治疗工具在开发疫苗、抗菌和抗癌治疗方面的各种应用。