UK Health Security Agency, Chilton, Didcot, OX11 0RQ, UK.
Sci Rep. 2023 Sep 28;13(1):16306. doi: 10.1038/s41598-023-43653-2.
Any potential positive effects conferred via sunlight exposure have to be carefully balanced against carcinogenic effects. Here we provide evidence UK sunlight exposure upregulates the cardio protectant nitric oxide (NO) within in vitro skin cell lines with negligible increases in DNA damage and cell death at 1 SED, when compared against unexposed samples. The whole of the ultraviolet A (UV-A) spectrum appears to be responsible for NO release, with efficiency higher at exposures closer to shorter UV-A wavelengths and decreasing with wavelength increases. These results support further in vivo work, which could be of benefit for demographics such as the elderly (that exhibit a natural decline in NO bioavailability).
任何通过阳光照射带来的潜在积极影响都必须与致癌作用仔细权衡。在这里，我们提供的证据表明，与未暴露的样本相比，英国阳光照射可上调体外皮肤细胞系中的保护心脏的一氧化氮（NO），而在 1 个 SED 时，对 DNA 损伤和细胞死亡的影响可忽略不计。整个长波紫外线 A（UV-A）光谱似乎都对 NO 的释放负责，在更接近较短的 UV-A 波长的暴露下效率更高，并且随着波长的增加而降低。这些结果支持进一步的体内研究，这可能对老年人（NO 生物利用度自然下降）等人群有益。
