Wang Jiang, Luo Lan-Zhu, Liang Dao-Miao, Guo Chao, Huang Zhi-Hong, Sun Guo-Ying, Wen Jie
Children Medical Center, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha 410013, Hunan Province, China.
Department of Hepatobiliary Surgery, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha 410013, Hunan Province, China.
World J Clin Oncol. 2023 Sep 24;14(9):324-334. doi: 10.5306/wjco.v14.i9.324.
Developing novel cancer therapies that exploit programmed cell death pathways holds promise for advancing cancer treatment. According to a recently published study in Science, copper death (cuproptosis) occurs when intracellular copper is overloaded, triggering aggregation of lipidated mitochondrial proteins and Fe-S cluster proteins. This intriguing phenomenon is triggered by the instability of copper ions. Understanding the molecular mechanisms behind cuproptosis and its associated genes, as identified by Tsvetkov, including ferredoxin 1, lipoic acid synthase, lipoyltransferase 1, dihydrolipid amide dehydrogenase, dihydrolipoamide transacetylase, pyruvate dehydrogenase α1, pyruvate dehydrogenase β, metallothionein, glutaminase, and cyclin-dependent kinase inhibitor 2A, may open new avenues for cancer therapy. Here, we provide a new understanding of the role of copper death and related genes in cancer.
开发利用程序性细胞死亡途径的新型癌症疗法有望推动癌症治疗的发展。根据最近发表在《科学》杂志上的一项研究，当细胞内铜过载时，会引发铜死亡，触发脂化线粒体蛋白和铁硫簇蛋白的聚集。这种有趣的现象是由铜离子的不稳定性引发的。了解由茨韦特科夫确定的铜死亡背后的分子机制及其相关基因，包括铁氧化还原蛋白1、硫辛酸合酶、硫辛酰转移酶1、二氢硫辛酰胺脱氢酶、二氢硫辛酰胺转乙酰基酶、丙酮酸脱氢酶α1、丙酮酸脱氢酶β、金属硫蛋白、谷氨酰胺酶和细胞周期蛋白依赖性激酶抑制剂2A，可能为癌症治疗开辟新途径。在此，我们对铜死亡及相关基因在癌症中的作用提供了新的认识。
