Gallavan R H, Shaw C, Murphy R F, Buchanan K D, Joffe S N, Jacobson E D
Am J Physiol. 1986 Nov;251(5 Pt 1):G649-55. doi: 10.1152/ajpgi.1986.251.5.G649.
The purpose of this study was to evaluate the role of neurotensin in the local regulation of the lipid-induced jejunal hyperemia. Total blood flow and the arteriovenous hormone concentration difference were measured in isolated jejunal loops of anesthetized dogs with either saline, bile (10% in normal saline), oleic acid (40 mM in normal saline), or oleic acid and bile in the lumen. The bile-oleic acid mixture produced a sustained increase (+25 +/- 3%) in jejunal blood flow, whereas neurotensin release reached a maximum (1.14 +/- 0.34 pmol X min-1 X 100 g-1) 2 min after initiation of the response and then returned to control. Venous neurotensin concentrations also reached a maximum (51 +/- 17 pmol/l) at 2 min. There were no significant changes in either blood flow or neurotensin release in response to the other test solutions. Intra-arterial infusion of neurotensin did not significantly decrease jejunal vascular resistance (-12 +/- 3%) until venous concentrations of 478 +/- 101 pmol/l were attained. It seems unlikely, then, that neurotensin plays any role in the regulation of the lipid-induced jejunal hyperemia.
本研究的目的是评估神经降压素在脂质诱导的空肠充血局部调节中的作用。在麻醉犬的离体空肠袢中，分别向肠腔内注入生理盐水、胆汁（生理盐水浓度为10%）、油酸（生理盐水浓度为40 mM）或油酸与胆汁的混合物，测量总血流量和动静脉激素浓度差。胆汁 - 油酸混合物使空肠血流量持续增加（+25±3%），而神经降压素释放量在反应开始后2分钟达到最大值（1.14±0.34 pmol·min⁻¹·100 g⁻¹），随后恢复至对照水平。静脉神经降压素浓度在2分钟时也达到最大值（51±17 pmol/L）。对其他测试溶液的反应中，血流量和神经降压素释放均无显著变化。动脉内注入神经降压素，直到静脉浓度达到478±101 pmol/L时，才使空肠血管阻力显著降低（-12±3%）。因此，神经降压素似乎不太可能在脂质诱导的空肠充血调节中发挥任何作用。
