Twinkle Reddipogu Havilah, Sain Yukta, Pinjar Mohammed Jaffer, Manik Khaleel Ahmed, Mondal Himel
Physiology, Great Eastern Medical School and Hospital, Ragolu, IND.
Medical School, Great Eastern Medical School and Hospital, Ragolu, IND.
Cureus. 2023 Aug 28;15(8):e44259. doi: 10.7759/cureus.44259. eCollection 2023 Aug.
Background While the hereditary component of asthma has been established, its influence on early respiratory function changes in otherwise healthy offspring remains to be explored. Dynamic lung function tests assess airflow in and out of the lungs, providing valuable insights into respiratory health and detecting potential airflow limitations. This study aimed to compare the dynamic lung functions between offspring of asthmatic and non-asthmatic parents. Methodology A case-control design was employed comprising 30 cases (offspring of asthmatic parents) and 30 controls (offspring of non-asthmatic parents). Lung function parameters including forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC ratio, forced expiratory flow between 25% and 75% of the FVC (FEF 25-75%), and maximum mid-expiratory flow at 50% of the FVC (Vmax 50%) were measured. Statistical analysis was conducted to compare the parameters between cases and controls using the unpaired t-test. Results The mean age of controls was 20.46 ± 2.82 years and the cases was 19.83 ± 1.41 years. The study revealed that cases exhibited lower FEV1 and Vmax 50% values compared to controls, indicating potential airflow limitations and altered mid-exhalation flow rates in the offspring of asthmatic parents. While trends were observed in FVC, FEV1/FVC ratio, and FEF 25-75%, these differences were not statistically significant. Conclusions The findings suggest a potential association between parental asthma and altered lung function parameters, specifically in FEV1 and Vmax 50%, among their offspring. These early respiratory function changes underscore the potential impact of hereditary factors on lung health. Healthcare professionals should take parental asthma into account when evaluating lung functions. This may lead to earlier detection and intervention. Further investigation is warranted to elucidate the underlying mechanisms and long-term implications of these findings.
背景 虽然哮喘的遗传因素已得到确认，但其对其他方面健康的后代早期呼吸功能变化的影响仍有待探索。动态肺功能测试评估进出肺部的气流，为呼吸健康提供有价值的见解并检测潜在的气流受限情况。本研究旨在比较哮喘患者父母的后代与非哮喘患者父母的后代之间的动态肺功能。
方法 采用病例对照设计，包括30例病例（哮喘患者父母的后代）和30例对照（非哮喘患者父母的后代）。测量肺功能参数，包括用力肺活量（FVC）、一秒用力呼气容积（FEV1）、FEV1/FVC比值、FVC的25%至75%之间的用力呼气流量（FEF 25-75%）以及FVC的50%时的最大呼气中期流量（Vmax 50%）。使用不成对t检验进行统计分析，以比较病例组和对照组之间的参数。
结果 对照组的平均年龄为20.46±2.82岁，病例组为19.83±1.41岁。研究表明，与对照组相比，病例组的FEV1和Vmax 50%值较低，表明哮喘患者父母的后代存在潜在的气流受限和呼气中期流速改变。虽然在FVC、FEV1/FVC比值和FEF 25-75%方面观察到了趋势，但这些差异无统计学意义。
结论 研究结果表明，父母患哮喘与后代肺功能参数改变之间可能存在关联，特别是在FEV1和Vmax 50%方面。这些早期呼吸功能变化突出了遗传因素对肺部健康的潜在影响。医疗保健专业人员在评估肺功能时应考虑父母是否患有哮喘。这可能会导致更早的检测和干预。有必要进行进一步调查以阐明这些发现的潜在机制和长期影响。
