Yu Xiangjiang, Andreo Jacopo, Walden Madeline, Del Campo Javier F, Basabe-Desmonts Lourdes, Benito-Lopez Fernando, Burg Thomas P, Wuttke Stefan
BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, Leioa, Vizcaya, 48940, Spain.
Ikerbasque, Basque Foundation for Science, Bilbao, 48009, Spain.
Small Methods. 2024 Jan;8(1):e2300603. doi: 10.1002/smtd.202300603. Epub 2023 Sep 29.
The Dean Flow, a physics phenomenon that accounts for the impact of channel curvature on fluid dynamics, has great potential to be used in microfluidic synthesis of nanoparticles. This study explores the impact of the Dean Flow on the synthesis of ZIF-8 particles. Several variables that influence the Dean Equation (the mathematical expression of Dean Flow) are tested to validate the applicability of this expression in microfluidic synthesis, including the flow rate, radius of curvature, channel cross sectional area, and reagent concentration. It is demonstrated that the current standard of reporting, providing only the flow rate and crucially not the radius of curvature, is an incomplete description that will invariably lead to irreproducible syntheses across different laboratories. An alternative standard of reporting is presented and it is demonstrated how the sleek and simple math of the Dean Equation can be used to precisely tune the final dimensions of high quality, monodisperse ZIF-8 nanoparticles between 40 and 700 nm.
迪恩流是一种解释通道曲率对流体动力学影响的物理现象，在纳米颗粒的微流控合成中具有巨大的应用潜力。本研究探讨了迪恩流对ZIF-8颗粒合成的影响。测试了几个影响迪恩方程（迪恩流的数学表达式）的变量，以验证该表达式在微流控合成中的适用性，包括流速、曲率半径、通道横截面积和试剂浓度。结果表明，目前仅报告流速而关键不报告曲率半径的标准是一种不完整的描述，必然会导致不同实验室之间的合成结果无法重现。本文提出了一种替代报告标准，并展示了迪恩方程简洁的数学运算如何用于精确调整40至700纳米之间高质量、单分散ZIF-8纳米颗粒的最终尺寸。
