Department of Clinical Research Center, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Cardiovascular Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
J Clin Sleep Med. 2024 Feb 1;20(2):229-235. doi: 10.5664/jcsm.10838.
Observational studies have demonstrated the association between the single-point measurement of oxygen saturation (SpO) level and mortality in the general population. This study aimed to evaluate whether nocturnal SpO level could predict all-cause mortality in a community-based population.
The study samples were obtained from the Sleep Heart Health Study, which included 2,280 men and 2,606 women (mean age, 63.8 ± 11.1 years). A pulse oximeter based on overnight in-home polysomnography was used to monitor SpO levels during total sleep time (SpO). Multivariable Cox proportional hazards analysis was performed to examine the association between nocturnal SpO and all-cause mortality.
During the follow-up period of 10.7 ± 3.0 years, 1,110 (22.7%) people died. After adjusting for confounding factors, multivariable Cox regression analysis showed that the average SpO (hazard ratio [HR] 0.93; 95% confidence interval [CI] 0.90-0.96, < .001) was associated with all-cause mortality. These findings remained stable in individuals with low and high apnea-hypopnea index levels. Additionally, maximum SpO (HR, 0.91; 95% CI, 0.87-0.96; = .001) and minimum SpO (HR, 0.98; 95% CI, 0.97-0.99; = .001) could predict all-cause mortality. A significant association between nocturnal hypoxemia and all-cause mortality was also observed.
Our findings highlight the importance of monitoring nocturnal SpO level and improving hypoxemia in the general populations.
Yan B, Gao Y, Zhang Z, Shi T, Chen Q. Nocturnal oxygen saturation is associated with all-cause mortality: a community-based study. . 2024;20(2):229-235.
观察性研究已经证明了人群中单点血氧饱和度（SpO）水平与死亡率之间的关联。本研究旨在评估社区人群中夜间 SpO 水平是否可预测全因死亡率。
研究样本来自睡眠心脏健康研究，其中包括 2280 名男性和 2606 名女性（平均年龄 63.8±11.1 岁）。使用基于夜间家庭多导睡眠图的脉搏血氧仪监测总睡眠时间（SpO）期间的 SpO 水平。采用多变量 Cox 比例风险分析来检验夜间 SpO 与全因死亡率之间的关系。
在 10.7±3.0 年的随访期间，有 1110 人（22.7%）死亡。调整混杂因素后，多变量 Cox 回归分析显示，平均 SpO（风险比[HR]0.93；95%置信区间[CI]0.90-0.96，<0.001）与全因死亡率相关。在低和高呼吸暂停低通气指数水平的个体中，这些发现仍然稳定。此外，最大 SpO（HR，0.91；95%CI，0.87-0.96；=0.001）和最小 SpO（HR，0.98；95%CI，0.97-0.99；=0.001）也可预测全因死亡率。夜间低氧血症与全因死亡率之间也存在显著关联。
我们的研究结果强调了监测夜间 SpO 水平和改善一般人群低氧血症的重要性。
Yan B, Gao Y, Zhang Z, Shi T, Chen Q. 夜间血氧饱和度与全因死亡率相关：一项基于社区的研究。 2024;20(2):229-235.
