Kauffman H M, Lawson R K, Adams M B, Sampson D
Transplant Proc. 1979 Mar;11(1):96-9.
Posttransplant hypersplenism, manifested by leukopenia and azathioprine intolerance, can be diagnosed with a high degree of accuracy and promptly reversed by emergency splenectomy. Functioning cadaver kidney homograft survival rates in patients undergoing posttransplant splenectomy are equal to that of patients undergoing pretransplant splenectomy and are statistically superior (p less than 0.01) to recipients who have never had their spleens removed. However, mortality (21%) for posttransplant splenectomy is excessively high when compared to our mortality (1.3%) for pretransplant splenectomy.
移植后脾功能亢进表现为白细胞减少和对硫唑嘌呤不耐受，诊断准确性高，紧急脾切除可迅速逆转。接受移植后脾切除患者的功能性尸体肾同种异体移植存活率与移植前脾切除患者相当，且在统计学上优于从未切除脾脏的受者（p<0.01）。然而，与我们移植前脾切除的死亡率（1.3%）相比，移植后脾切除的死亡率（21%）过高。
