Li Congxin, Peng Kaixin, Xiao Siqi, Long Yuanyuan, Yu Qin
Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Institute of Liver and Gastrointestinal Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Cell Death Discov. 2023 Sep 29;9(1):361. doi: 10.1038/s41420-023-01666-w.
Inflammatory Bowel Disease (IBD), a chronic nonspecific intestinal inflammatory disease, is comprised of Ulcerative Colitis (UC) and Crohn's Disease (CD). IBD is closely related to a systemic inflammatory reaction and affects the progression of many intestinal and extraintestinal diseases. As one of the representative bacteria for probiotic-assisted therapy in IBD, multiple strains of Lactobacillus have been proven to alleviate intestinal damage and strengthen the intestinal immunological barrier, epithelial cell barrier, and mucus barrier. Lactobacillus also spares no effort in the alleviation of IBD-related diseases such as Colitis-associated Colorectal cancer (CAC), Alzheimer's Disease (AD), Depression, Anxiety, Autoimmune Hepatitis (AIH), and so on via gut-brain axis and gut-liver axis. This article aims to discuss the role of Lactobacillus in IBD and IBD-related diseases, including its underlying mechanisms and related curative strategies from the present to the future.
炎症性肠病（IBD）是一种慢性非特异性肠道炎症性疾病，由溃疡性结肠炎（UC）和克罗恩病（CD）组成。IBD与全身炎症反应密切相关，并影响许多肠道和肠外疾病的进展。作为IBD益生菌辅助治疗的代表性细菌之一，多种乳酸杆菌菌株已被证明可减轻肠道损伤，并加强肠道免疫屏障、上皮细胞屏障和黏液屏障。乳酸杆菌还通过肠-脑轴和肠-肝轴不遗余力地减轻与IBD相关的疾病，如结肠炎相关结直肠癌（CAC）、阿尔茨海默病（AD）、抑郁症、焦虑症、自身免疫性肝炎（AIH）等。本文旨在探讨乳酸杆菌在IBD及IBD相关疾病中的作用，包括其潜在机制以及从现在到未来的相关治疗策略。
