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炎症性肠病的治疗：烟酰胺单核苷酸对肠道屏障和肠道微生物群的潜在影响。

Treatment of inflammatory bowel disease: Potential effect of NMN on intestinal barrier and gut microbiota.

作者信息

Huang Pan, Wang Xuxin, Wang Siyu, Wu Zhipeng, Zhou Zhengrong, Shao Genbao, Ren Caifang, Kuang Meiqian, Zhou Yan, Jiang Anqi, Tang Weihong, Miao Jianye, Qian Xin, Gong Aihua, Xu Min

机构信息

Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang 212013, PR China.

School of Medicine, Jiangsu University, Zhenjiang 212013, PR China.

出版信息

Curr Res Food Sci. 2022 Sep 5;5:1403-1411. doi: 10.1016/j.crfs.2022.08.011. eCollection 2022.

DOI:10.1016/j.crfs.2022.08.011
PMID:36105890
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9464647/
Abstract

Nicotinamide mononucleotide (NMN) exerts physiological effects in mammals through its conversion to nicotinamide adenine dinucleotide (NAD). In this study, we established experimental models of colitis by mixing drinking water of C57BL/6J mice with dextran sodium sulphate (DSS), and then fed them with the same concentration of NMN or at the same time. After NMN treatment, we observed improved morphology of inflamed intestines, slightly restored length of colon, improved barrier function and reduced proinflammatory factors expression in serum. Also, significant alterations in the composition and abundance of intestinal flora in IBD mice were found. The abundance of , , and , considered as beneficial bacteria, increased, while and unclassifiably decreased. Taken together, these results suggest that NMN may improve intestinal inflammation, reduce intestinal mucosal permeability and repair gut flora dysbiosis in IBD.

摘要

烟酰胺单核苷酸（NMN）通过转化为烟酰胺腺嘌呤二核苷酸（NAD）在哺乳动物中发挥生理作用。在本研究中，我们通过将C57BL/6J小鼠的饮用水与葡聚糖硫酸钠（DSS）混合建立了结肠炎实验模型，然后用相同浓度的NMN喂养它们或同时进行处理。NMN处理后，我们观察到炎症肠道的形态得到改善，结肠长度略有恢复，屏障功能改善，血清中促炎因子表达降低。此外，还发现炎症性肠病（IBD）小鼠肠道菌群的组成和丰度有显著变化。被认为是有益菌的、、和的丰度增加，而和无法分类地减少。综上所述，这些结果表明NMN可能改善肠道炎症，降低肠道黏膜通透性，并修复IBD中的肠道菌群失调。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81c4/9464647/1403de17a341/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81c4/9464647/8a557f2cc689/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81c4/9464647/6fe72544bf41/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81c4/9464647/2b6c8273ee1e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81c4/9464647/5c09698a91f9/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81c4/9464647/ba5fefd31092/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81c4/9464647/9c3940ddf8fb/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81c4/9464647/1403de17a341/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81c4/9464647/8a557f2cc689/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81c4/9464647/6fe72544bf41/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81c4/9464647/2b6c8273ee1e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81c4/9464647/5c09698a91f9/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81c4/9464647/ba5fefd31092/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81c4/9464647/9c3940ddf8fb/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81c4/9464647/1403de17a341/gr6.jpg

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引用本文的文献

[1]
Curcumin Ameliorates DSS-Induced Colitis in Mice Through Modulation of Gut Microbiota and Metabolites.

Life (Basel). 2025-7-21

[2]
NMN reverses D-galactose-induced neurodegeneration and enhances the intestinal barrier of mice by activating the Sirt1 pathway.

Front Pharmacol. 2025-4-10

[3]
Long non-coding RNA ANRIL/p65 negative feedback loop protects intestinal barrier function in inflammatory bowel disease.

Noncoding RNA Res. 2025-3-14

[4]
Lactobacillus rhamnosus GG induces STING-dependent IL-10 in intestinal monocytes and alleviates inflammatory colitis in mice.

J Clin Invest. 2025-2-3

[5]
Advancements in NMN biotherapy and research updates in the field of digestive system diseases.

J Transl Med. 2024-8-30

[6]
Nicotinamide Mononucleotide Supplementation: Understanding Metabolic Variability and Clinical Implications.

Metabolites. 2024-6-18

[7]
Excessive nucleic acid R-loops induce mitochondria-dependent epithelial cell necroptosis and drive spontaneous intestinal inflammation.

Proc Natl Acad Sci U S A. 2024-1-2

[8]
Dietary Betaine Supplementation Enhances Colonic Barrier Function through the Nrf2/Keap1 and TLR4-NF-κB/MAPK Signaling Pathways and Alters Colonic Microbiota in Bama Mini-Pigs.

Antioxidants (Basel). 2023-10-29

[9]
The role of Lactobacillus in inflammatory bowel disease: from actualities to prospects.

Cell Death Discov. 2023-9-29

[10]
Epithelial NAD depletion drives mitochondrial dysfunction and contributes to intestinal inflammation.

Front Immunol. 2023

本文引用的文献

[1]
Analysis of phenolic compounds in pickled chayote and their effects on antioxidant activities and cell protection.

Food Res Int. 2022-7

[2]
NMN Maintains Intestinal Homeostasis by Regulating the Gut Microbiota.

Front Nutr. 2021-7-29

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A purified membrane protein from or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8 T cells in mice.

Gut. 2020-11

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The role of the gut microbiota in the treatment of inflammatory bowel diseases.

Microb Pathog. 2019-10-3

[5]
Targeting Gut Microbiota for the Prevention and Management of Diabetes Mellitus by Dietary Natural Products.

Foods. 2019-9-25

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The clinicopathological significance of ubiquitin-conjugating enzyme E2C, leucine-rich repeated-containing G protein-coupled receptor, WW domain-containing oxidoreductase, and vasculogenic mimicry in invasive breast carcinoma.

Medicine (Baltimore). 2019-4

[7]
Genetic Factors and the Intestinal Microbiome Guide Development of Microbe-Based Therapies for Inflammatory Bowel Diseases.

Gastroenterology. 2019-3-14

[8]
Vitexin ameliorates high fat diet-induced obesity in male C57BL/6J mice via the AMPKα-mediated pathway.

Food Funct. 2019-3-15

[9]
Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule.

Biomolecules. 2019-1-21

[10]
Mechanisms regulating intestinal barrier integrity and its pathological implications.

Exp Mol Med. 2018-8-16

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