Perioperative blood transfusion associated with infectious complications after colorectal cancer operations.

We prospectively studied 168 consecutive patients with colorectal cancer to identify perioperative determinants of infectious complications. All patients received preoperative bowel preparation with laxatives, enemas, oral neomycin and erythromycin base, and intravenous cefazolin. Age, sex, admission hematocrit value, operative procedure, specimen length, duration of operation, blood loss, transfusions, tumor size, tumor differentiation, nodal status, and Dukes' stage were evaluated in relation to infectious complications using multivariate analysis. Infectious complications developed in 24 of the 168 patients in the study (14 percent) and these accounted for the four deaths. Blood transfusion (p = 0.0100) and admission hematocrit value (p = 0.0191) were significantly related to postoperative infectious complications. Low admission hematocrit values appeared to protect patients from infectious complications. Patients who had postoperative infectious complications received 2.14 +/- 2.75 units of blood compared with 0.82 +/- 1.37 units in patients without infectious complications (p = 0.0005). Although blood transfusion was associated with high operative blood loss, prolonged procedures, and large specimens (p less than 0.005), none of these factors was significantly associated with infectious complications (p greater than 0.10). Blood transfusion is immunosuppressive in other clinical situations and may be a more significant factor affecting postoperative immune function and susceptibility to infectious complications than previously recognized.