Opt Lett. 2023 Oct 1;48(19):5129-5132. doi: 10.1364/OL.501851.
Neuronal hyperexcitability promises an early biomarker of Alzheimer's disease (AD). However, in vivo detection of neuronal hyperexcitability in the brain is technically challenging. The retina, one part of the central nervous system, presents a unique window for noninvasive monitoring of the brain function. This study aims to test the feasibility of using intrinsic signal optoretinography (ORG) for mapping retinal hyperexcitability associated with early-stage AD. Custom-designed optical coherence tomography (OCT) was employed for both morphological measurement and functional ORG of wild-type mice and 3xTg-AD mice. Comparative analysis revealed AD-induced retinal photoreceptor hyperexcitability prior to detectable structural degeneration.
神经元过度兴奋有望成为阿尔茨海默病（AD）的早期生物标志物。然而，在活体中检测大脑中的神经元过度兴奋在技术上具有挑战性。视网膜作为中枢神经系统的一部分，为非侵入性监测大脑功能提供了一个独特的窗口。本研究旨在测试使用固有信号光视网膜电图（ORG）来绘制与早期 AD 相关的视网膜过度兴奋的可行性。本研究使用定制设计的光学相干断层扫描（OCT）对野生型小鼠和 3xTg-AD 小鼠进行形态学测量和功能 ORG。比较分析显示 AD 引起的视网膜光感受器过度兴奋发生在可检测的结构退化之前。
